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Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis
Wu, Qihao1,2; Li, Xu-Wen1; Li, Heng1; Yao, Li-Gong1; Tang, Wei1; Miao, Ze-Hong1; Wang, Hong3; Guo, Yue-Wei1,3
2019-01-15
Source PublicationBioorganic & medicinal chemistry letters
ISSN1464-3405
Volume29Issue:2Pages:185-188
AbstractDifferent chemotypes of Sinularia flexibilis exist in the Hainan island. Thus, a collection of this soft coral from a location different from the one of our previous study afforded three novel cembranoid esters featuring a n-butyl alcohol moiety, a structural element rare in natural products of both terrestrial and marine origin. The structures of the new compounds were elucidated by detailed spectroscopic analysis and by the comparison of their spectroscopic data with those reported in the literature. In addition, the absolute stereochemistry of the previously reported diepoxycembrene (9) was first time determined by the X-ray diffraction analysis. In bioassays, compounds 6-8 exhibited strong anti-inflammatory effect with IC values of 2.7, 4.7, and 4.2 μM, respectively, whereas compound 5 displayed cytotoxicity against several cancer cells with IC values ranging from 8.9 to 27.4 μM. A preliminary structural-activity relationship (SAR) was also described.
SubtypeArticle
DOI10.1016/j.bmcl.2018.12.004
Indexed ByPubMed
Language英语
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://119.78.100.183/handle/2S10ELR8/266360
Collection天然药物化学研究室_郭跃伟课题组
Corresponding AuthorWang, Hong; Guo, Yue-Wei
Affiliation1.State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Zhangjiang Hi-Tech Park, Shanghai 201203, China;
2.College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China;
3.College of Pharmaceutical Sciences, Zhejiang University of Technology, Hangzhou 310014, China
First Author AffilicationState Key Laboratory of Drug Research
Corresponding Author AffilicationState Key Laboratory of Drug Research
Recommended Citation
GB/T 7714
Wu, Qihao,Li, Xu-Wen,Li, Heng,et al. Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis[J]. Bioorganic & medicinal chemistry letters,2019,29(2):185-188.
APA Wu, Qihao.,Li, Xu-Wen.,Li, Heng.,Yao, Li-Gong.,Tang, Wei.,...&Guo, Yue-Wei.(2019).Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis.Bioorganic & medicinal chemistry letters,29(2),185-188.
MLA Wu, Qihao,et al."Bioactive polyoxygenated cembranoids from a novel Hainan chemotype of the soft coral Sinularia flexibilis".Bioorganic & medicinal chemistry letters 29.2(2019):185-188.
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