Knowledge Management System of Shanghai Institute of Materia Medica, CAS
| Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax | |
Xu, Yunshao1; Shi, Wei1; Feng, Lu2,3; Cao, Jun1; Feng, Zheling1; Zhang, Qingwen1; Lu, Jinjian1; Ye, Yang2,3,4 ; Lin, Ligen1
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| 2020-11-22 | |
| Source Publication | NATURAL PRODUCT RESEARCH (IF:1.928[JCR-2017],1.657[5-Year]) |
| ISSN | 1478-6419 |
| Pages | 10 |
| Abstract | The seeds of Caesalpinia minax Hance have shown anti-tumor potential, while the chemical principle is still unknown. In a search for anti-tumor compounds, six new cassane-type diterpenoids, 12-demethylcaesalpin G (1), caesalpinolide H (2), 12-demethylcaesalpin H (3), caesalpinolide J (4), 12-O-ethyl neocaesalpin B (5), and 3-deacetyldecapetpene B (6), were isolated from the seeds of C. minax Hance, along with fifteen known analogues. The structures of the new compounds were established by means of spectroscopic techniques (NMR, HRESIMS and IR). The absolute configurations of the new compounds were determined by their ECD spectra. All of the new compounds were tested for their anti-proliferative activity against human lung cancer A549 cells, breast cancer MCF-7 cells, and ovarian cancer HEY cells. The results indicated that only compound 6 displayed moderate cytotoxicity against three cancer cell lines. Thus, the opening of furan ring in cassane-type diterpenoids might enhance the cytotoxic activity. |
| Keyword | Caesalpinia minax Fabaceae cassane diterpenoids cytotoxic activity |
| DOI | 10.1080/14786419.2020.1853729 |
| Indexed By | SCI |
| Language | 英语 |
| Funding Project | University of Macau[MYRG2017-00109-ICMS] ; University of Macau[MYRG2018-00037ICMS] ; National Natural Science Foundation of China[81872754] ; Key-Area Research and Development Program of Guangdong Province, China[2020B1111110003] ; Open Research Fund of Chengdu University of Traditional Chinese Medicine Key Laboratory of Systematic Research of Distinctive Chinese Medicine Resources in Southwest China[2020GZ2011011] |
| WOS Research Area | Chemistry ; Pharmacology & Pharmacy |
| WOS Subject | Chemistry, Applied ; Chemistry, Medicinal |
| WOS ID | WOS:000596647100001 |
| Publisher | TAYLOR & FRANCIS LTD |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://119.78.100.183/handle/2S10ELR8/296188 |
| Collection | 新药研究国家重点实验室 |
| Corresponding Author | Lin, Ligen |
| Affiliation | 1.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Macau, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai, Peoples R China 4.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai, Peoples R China |
| Recommended Citation GB/T 7714 | Xu, Yunshao,Shi, Wei,Feng, Lu,et al. Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax[J]. NATURAL PRODUCT RESEARCH,2020:10. |
| APA | Xu, Yunshao.,Shi, Wei.,Feng, Lu.,Cao, Jun.,Feng, Zheling.,...&Lin, Ligen.(2020).Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax.NATURAL PRODUCT RESEARCH,10. |
| MLA | Xu, Yunshao,et al."Anti-proliferative cassane-type diterpenoids from the seeds of Caesalpinia minax".NATURAL PRODUCT RESEARCH (2020):10. |
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