Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages

doi:10.1016/j.phytochem.2021.112955

KMS@SIMM > 新药研究国家重点实验室

	Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages
	Wang, Qiaoqiao 1,2,3,4; Zhang, Tian 5; Ke, Chang-Qiang1,2 ; Tang, Chunping1,2 ; Yao, Sheng1,2 ; Lin, Ligen 5; Ye, Yang1,2,3,4
	2021-12-01
发表期刊	PHYTOCHEMISTRY (IF:3.186[JCR-2017],3.041[5-Year])
ISSN	0031-9422
卷号	192 页码:10
摘要	Sesquiterpene lactones supply a variety of scaffolds for the development of anti-inflammatory drugs. In this study, eight undescribed guaianolides, i.e., lavandolides A-H, were isolated from the whole plants of Artemisia codonocephala, together with five known analogues. Their planar structures and relative configurations were elucidated by spectroscopic measurements, and their absolute configurations were determined by electronic circulardichroism spectra and single crystal X-ray diffraction experiments. The nitric oxide inhibitory effect of all the isolates was assessed on lipopolysaccharide stimulated THP-1 macrophages. Lavandolide D showed a potent inhibitory effect on NO production, with IC50 values of 3.31 +/- 0.74 mu M. Furthermore, lavandolide D inhibited NOD-, LRR-and pyrin domain-containing protein 3 inflammasome-mediated interleukin-1 beta production through activating autophagy.
关键词	Artemisia codonocephala Asteraceae Guaianolides Anti-inflammation IL-1 beta NLRP3
WOS关键词	SESQUITERPENE LACTONES ; GENUS
DOI	10.1016/j.phytochem.2021.112955
收录类别	SCI
语种	英语
资助项目	Science and Technology Commission of Shanghai Municipality[20430780300] ; Science and Technology Commission of Shanghai Municipality[19431908100] ; Key-Area Research and Development Program of Guangdong Province[2020B0303070002] ; University of Macau[MYRG2018-00037-ICMS]
WOS研究方向	Biochemistry & Molecular Biology ; Plant Sciences
WOS类目	Biochemistry & Molecular Biology ; Plant Sciences
WOS记录号	WOS:000704441000016
出版者	PERGAMON-ELSEVIER SCIENCE LTD
引用统计	被引频次：8[WOS] [WOS记录] [WOS相关记录]
文献类型	期刊论文
条目标识符	http://119.78.100.183/handle/2S10ELR8/298425
专题	新药研究国家重点实验室
通讯作者	Ye, Yang
作者单位	1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Nat Prod Chem Dept, Shanghai 201203, Peoples R China 3.Shanghai Tech Univ, Sch Life Sci & Technol, Shanghai 201203, Peoples R China 4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 5.Univ Macau, Inst Chinese Med Sci, State Key Lab Qual Res Chinese Med, Taipa 999078, Macao, Peoples R China
第一作者单位	新药研究国家重点实验室; 天然药物化学研究室
通讯作者单位	新药研究国家重点实验室; 天然药物化学研究室
推荐引用方式 GB/T 7714	Wang, Qiaoqiao,Zhang, Tian,Ke, Chang-Qiang,et al. Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages[J]. PHYTOCHEMISTRY,2021,192:10.
APA	Wang, Qiaoqiao.,Zhang, Tian.,Ke, Chang-Qiang.,Tang, Chunping.,Yao, Sheng.,...&Ye, Yang.(2021).Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages.PHYTOCHEMISTRY,192,10.
MLA	Wang, Qiaoqiao,et al."Guaianolides from Artemisia codonocephala suppress interleukine-1 beta secretion in macrophages".PHYTOCHEMISTRY 192(2021):10.