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Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy
Zhai, Yihui1,3; Zhang, Wen2,4; Wang, Jinming5,6; Kong, Ying7; Rong, Rong7; Lang, Tianqun1,3; Zheng, Chao2,4; Wang, Yanke8; Yu, Yang8; Zhu, Helen He5,6; Cai, Ying1,3,9; Zhang, Pengcheng10,11,12; Li, Yaping1,3,9
2024-12-03
发表期刊ADVANCED SCIENCE
页码14
摘要Interleukin 15 (IL15) is crucial for fostering the survival and proliferation of nature killer (NK) cells and cytotoxic T lymphocytes (CTLs), playing a pivotal role in tumor control. However, IL15 supplementary therapy encounters challenges such as systemic inflammation and non-specific stimulation of cancer cells. Herein, a nanovesicle termed DoxFILN, comprising a membrane presenting IL15/IL15 receptor alpha complexes (IL15c) and a core of doxorubicin-loaded ferritin (Dox-Fn) are reported. The DoxFILN significantly enhances the densities and activities of intratumoral CTLs and NK cells. Mechanistically, DoxFILN undergoes deshelling in the acidic tumor microenvironment, releasing Dox-Fn and membrane-bound IL15c. Dox-Fn selectively target transferrin receptors on cancerous cells, facilitating intracellular Dox release and inducing immunogenic cell death. Concurrently, membrane-bound IL15c recognizes and activates IL15 receptor beta/gamma c heterodimers, leading to a remarkable increase in the proliferation and activation of CTLs (16-fold and 28-fold) and NK cells (37-fold and 50-fold). The IL15-displaying nanovesicle introduced here holds promise as a potential platform for immunochemotherapy in the treatment of cancer.
关键词CTLs IL15, immunotherapy nanovesicles NK cells
WOS关键词T-CELLS ; MEMBRANE ; IL-15 ; RECEPTOR ; NANOPARTICLES ; FAMILY ; CHAIN ; IL15
DOI10.1002/advs.202409194
收录类别SCI
资助项目National Key R&D Program of China ; National Natural Science Foundation of China[32371457] ; National Natural Science Foundation of China[32171374] ; National Natural Science Foundation of China[31930066] ; Shandong Laboratory Program[SYS202205] ; Chinese Academy of Sciences ; [2022YFC3401404]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
WOS类目Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary
WOS记录号WOS:001368502300001
出版者WILEY
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文献类型期刊论文
条目标识符http://119.78.100.183/handle/2S10ELR8/314972
专题新药研究国家重点实验室
通讯作者Cai, Ying; Zhang, Pengcheng; Li, Yaping
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.China State Inst Pharmaceut Ind, Shanghai 201203, Peoples R China
5.Shanghai Jiao Tong Univ, Ren Ji Hosp, Renji Med X Stem Cell Res Ctr, Sch Med,Dept Urol,State Key Lab Oncogenes & Relate, Shanghai 200127, Peoples R China
6.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200127, Peoples R China
7.Yantai Inst Mat Med, Yantai 264000, Shandong, Peoples R China
8.Zhangjiang Lab, Natl Facil Prot Sci Shanghai, Shanghai 201210, Peoples R China
9.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
10.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 201210, Peoples R China
11.ShanghaiTech Univ, State Key Lab Adv Med Mat & Devices, Shanghai 201210, Peoples R China
12.Shanghai Clin Res & Trial Ctr, Shanghai 201203, Peoples R China
第一作者单位新药研究国家重点实验室
通讯作者单位新药研究国家重点实验室
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GB/T 7714
Zhai, Yihui,Zhang, Wen,Wang, Jinming,et al. Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy[J]. ADVANCED SCIENCE,2024:14.
APA Zhai, Yihui.,Zhang, Wen.,Wang, Jinming.,Kong, Ying.,Rong, Rong.,...&Li, Yaping.(2024).Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy.ADVANCED SCIENCE,14.
MLA Zhai, Yihui,et al."Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy".ADVANCED SCIENCE (2024):14.
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