Knowledge Management System of Shanghai Institute of Materia Medica, CAS
Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy | |
Zhai, Yihui1,3; Zhang, Wen2,4; Wang, Jinming5,6; Kong, Ying7; Rong, Rong7; Lang, Tianqun1,3; Zheng, Chao2,4; Wang, Yanke8; Yu, Yang8; Zhu, Helen He5,6; Cai, Ying1,3,9; Zhang, Pengcheng10,11,12; Li, Yaping1,3,9![]() | |
2024-12-03 | |
发表期刊 | ADVANCED SCIENCE |
页码 | 14 |
摘要 | Interleukin 15 (IL15) is crucial for fostering the survival and proliferation of nature killer (NK) cells and cytotoxic T lymphocytes (CTLs), playing a pivotal role in tumor control. However, IL15 supplementary therapy encounters challenges such as systemic inflammation and non-specific stimulation of cancer cells. Herein, a nanovesicle termed DoxFILN, comprising a membrane presenting IL15/IL15 receptor alpha complexes (IL15c) and a core of doxorubicin-loaded ferritin (Dox-Fn) are reported. The DoxFILN significantly enhances the densities and activities of intratumoral CTLs and NK cells. Mechanistically, DoxFILN undergoes deshelling in the acidic tumor microenvironment, releasing Dox-Fn and membrane-bound IL15c. Dox-Fn selectively target transferrin receptors on cancerous cells, facilitating intracellular Dox release and inducing immunogenic cell death. Concurrently, membrane-bound IL15c recognizes and activates IL15 receptor beta/gamma c heterodimers, leading to a remarkable increase in the proliferation and activation of CTLs (16-fold and 28-fold) and NK cells (37-fold and 50-fold). The IL15-displaying nanovesicle introduced here holds promise as a potential platform for immunochemotherapy in the treatment of cancer. |
关键词 | CTLs IL15, immunotherapy nanovesicles NK cells |
WOS关键词 | T-CELLS ; MEMBRANE ; IL-15 ; RECEPTOR ; NANOPARTICLES ; FAMILY ; CHAIN ; IL15 |
DOI | 10.1002/advs.202409194 |
收录类别 | SCI |
资助项目 | National Key R&D Program of China ; National Natural Science Foundation of China[32371457] ; National Natural Science Foundation of China[32171374] ; National Natural Science Foundation of China[31930066] ; Shandong Laboratory Program[SYS202205] ; Chinese Academy of Sciences ; [2022YFC3401404] |
WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
WOS类目 | Chemistry, Multidisciplinary ; Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary |
WOS记录号 | WOS:001368502300001 |
出版者 | WILEY |
引用统计 | 正在获取...
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文献类型 | 期刊论文 |
条目标识符 | http://119.78.100.183/handle/2S10ELR8/314972 |
专题 | 新药研究国家重点实验室 |
通讯作者 | Cai, Ying; Zhang, Pengcheng; Li, Yaping |
作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 501 Haike Rd, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Ctr Pharmaceut, 501 Haike Rd, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.China State Inst Pharmaceut Ind, Shanghai 201203, Peoples R China 5.Shanghai Jiao Tong Univ, Ren Ji Hosp, Renji Med X Stem Cell Res Ctr, Sch Med,Dept Urol,State Key Lab Oncogenes & Relate, Shanghai 200127, Peoples R China 6.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200127, Peoples R China 7.Yantai Inst Mat Med, Yantai 264000, Shandong, Peoples R China 8.Zhangjiang Lab, Natl Facil Prot Sci Shanghai, Shanghai 201210, Peoples R China 9.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China 10.ShanghaiTech Univ, Sch Biomed Engn, Shanghai 201210, Peoples R China 11.ShanghaiTech Univ, State Key Lab Adv Med Mat & Devices, Shanghai 201210, Peoples R China 12.Shanghai Clin Res & Trial Ctr, Shanghai 201203, Peoples R China |
第一作者单位 | 新药研究国家重点实验室 |
通讯作者单位 | 新药研究国家重点实验室 |
推荐引用方式 GB/T 7714 | Zhai, Yihui,Zhang, Wen,Wang, Jinming,et al. Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy[J]. ADVANCED SCIENCE,2024:14. |
APA | Zhai, Yihui.,Zhang, Wen.,Wang, Jinming.,Kong, Ying.,Rong, Rong.,...&Li, Yaping.(2024).Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy.ADVANCED SCIENCE,14. |
MLA | Zhai, Yihui,et al."Interleukin 15-Presenting Nanovesicles with Doxorubicin-Loaded Ferritin Cores for Cancer Immunochemotherapy".ADVANCED SCIENCE (2024):14. |
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