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Bicyclic polyprenylated acylphloroglucinol-related meroterpenoids as potent DRAK2 inhibitors from Hypericum patulum 期刊论文
PHYTOCHEMISTRY, 2025, 卷号: 232, 页码: 10
Authors:  Huang, Jin-Chang;  Jia, Xin-Yu;  Lv, Yi-Fan;  Xu, Hong-Hong;  Han, Ming;  Yu, Qiang-Qiang;  Lu, Yu-Ting;  Yang, Hong-Xun;  Yang, Yang;  Li, Jing-Ya;  Hou, Ai-Jun
Favorite  |  View/Download：5/0  |  Submit date：2025/04/01
Hypericum patulum  Hypericaceae  Meroterpenoids  Hyperpatins A-H  Death-associated protein kinase-related  apoptosis-inducing kinase 2  Glucose-stimulated insulin secretion  
Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors 期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1318, 页码: 13
Authors:  Tang, Mingze;  Zhou, Xuan;  Shen, Qianqian;  Fang, Chen;  Peng, Xia;  Ji, Yinchun;  Zhu, Guijun;  Geng, Meiyu;  Chen, Yi;  Duan, Wenhu;  Ai, Jing;  Zhang, Hefeng
Favorite  |  View/Download：284/0  |  Submit date：2024/08/22
Receptor -interacting protein kinase 1  Histone deacetylases  Inhibitor  Molecular dynamics (MD) simulation  ADMET analysis  
Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors 期刊论文
ARCHIV DER PHARMAZIE, 2024, 页码: 16
Authors:  An, Yuxiang;  Peng, Xia;  Wang, Tianchen;  Liu, Kaiyuan;  Feng, Dazhi;  Fang, Chen;  Zhou, Xuan;  Geng, Meiyu;  Duan, Wenhu;  Ai, Jing;  Zhang, Hefeng
Favorite  |  View/Download：20/0  |  Submit date：2024/12/25
inhibitor  pharmacokinetic study  pyridazin-4-one  receptor-interacting protein kinase 1  selectivity  
13,14-seco seco withaphysalins from Physalis minima and their inhibitory effects on NLRP3 inflammasome activation 期刊论文
BIOORGANIC CHEMISTRY, 2024, 卷号: 151, 页码: 12
Authors:  Hu, Bintao;  Peng, Xia;  Tang, Chunping;  Geng, Meiyu;  Yao, Sheng;  Ai, Jing;  Ye, Yang
Favorite  |  View/Download：82/0  |  Submit date：2024/09/26
Physalis minima  NLRP3  Anti-inflammatory  13,14-seco withaphysalin  
Design, synthesis, and structure-activity relationship studies of 6,7-dihydro-5H-pyrrolo[1,2-b][1,2,4]triazole derivatives as necroptosis inhibitors 期刊论文
RSC MEDICINAL CHEMISTRY, 2024, 卷号: 15, 期号: 7, 页码: 2514-2526
Authors:  Jin, Zechen;  Dai, Yang;  Ji, Yinchun;  Peng, Xia;  Duan, Wenhu;  Ai, Jing;  Zhang, Hefeng
Favorite  |  View/Download：58/0  |  Submit date：2024/08/20
Discovery and optimization of 3-(indolin-5-yloxy)pyridin-2-amine derivatives as potent necroptosis inhibitors 期刊论文
ARCHIV DER PHARMAZIE, 2024, 页码: 21
Authors:  Lan, Yaohan;  Ji, Yinchun;  Peng, Xia;  Duan, Wenhu;  Geng, Meiyu;  Ai, Jing;  Zhang, Hefeng
Favorite  |  View/Download：98/0  |  Submit date：2024/08/22
autoimmune disease  necroptosis inhibitor  pharmacokinetic profile  receptor interacting protein kinase 1 (RIPK1)  structural optimization  
Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2024, 页码: 7
Authors:  You, Jin-Qiu;  Jin, Yun-Qi;  Li, Meng-Yu;  Zhang, Bo-Chao;  Sun, Xin-Yu;  Ding, Chun-Yong;  Li, Jing-Ya;  Hou, Ai-Jun
Favorite  |  View/Download：39/0  |  Submit date：2024/06/27
Natural products  Hypericum lancasteri  Meroterpenoids  Structure elucidation  Inflammation  
Tumor-targeted PROTAC prodrug nanoplatform enables precise protein degradation and combination cancer therapy 期刊论文
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 12
Authors:  Zou, Zhi-feng;  Yang, Lei;  Nie, Hui-jun;  Gao, Jing;  Lei, Shu-min;  Lai, Yi;  Zhang, Fan;  Wagner, Ernst;  Yu, Hai-jun;  Chen, Xiao-hua;  Xu, Zhi-ai
Favorite  |  View/Download：43/0  |  Submit date：2024/05/22
proteolysis-targeting chimeras  tumor-targeted delivery  precise protein degradation  combination therapy  triple-negative breast cancer  
Formyl phloroglucinol meroterpenoids from the leaves of Eucalyptus globulus subsp. maidenii and their ATP-citrate lyase inhibitory activities 期刊论文
FITOTERAPIA, 2024, 卷号: 173, 页码: 6
Authors:  Hu, Zhu;  Liu, Yi-Nan;  Yu, Mei-Hua;  Hou, Ai -Jun;  Li, Jing-Ya;  Li, Ying-Xia;  Lei, Chun
Favorite  |  View/Download：38/0  |  Submit date：2024/03/13
Eucalyptus globulus subsp. maidenii  Meroterpenoids  ATP-citrate lyase  
Discovery of a 1,6-naphthyridin-4-one-based AXL inhibitor with improved pharmacokinetics and enhanced in vivo antitumor efficacy 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 265, 页码: 17
Authors:  Lan, Yaohan;  Peng, Xia;  Ji, Yinchun;  Su, Yi;  Duan, Wenhu;  Ai, Jing;  Zhang, Hefeng
Favorite  |  View/Download：73/0  |  Submit date：2024/02/27
AXL inhibitor  In vivo antitumor efficacy  6-Naphthyridin-4-one derivatives  Scaffold hopping  Structure-based drug design  
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