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浏览/检索结果: 共1567条，第1-10条 帮助

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BMAL1/PGC1a4-FNDC5/irisin axis impacts distinct outcomes of time-of-day resistance exercise 期刊论文
JOURNAL OF SPORT AND HEALTH SCIENCE, 2025, 卷号: 14, 页码: 23
作者:  Guo, Mingwei;  Shen, Fei;  Guo, Xiaozhen;  Zhang, Jun;  Ma, Ying;  Wu, Xia;  Zuo, Hui;  Yao, Jing;  Hu, Yepeng;  Wang, Dongmei;  Li, Yu;  Li, Jin;  Qiu, Jin;  Yu, Jian;  Meng, Meiyao;  Zheng, Ying;  Chen, Xin;  Gong, Mingkai;  Liu, Kailin;  Jin, Ling;  Ren, Xiangyu;  Zhang, Qiang;  Zhao, Yu;  Gu, Xuejiang;  Shen, Feixia;  Li, Dali;  Gao, Liangcai;  Liu, Chang;  Zhou, Fei;  Li, Mian;  Wang, Jiqiu;  Ding, Shuzhe;  Ma, Xinran;  Lu, Jian;  Xie, Cen;  Xiao, Junjie;  Xu, Lingyan
收藏  |  浏览/下载：41/0  |  提交时间：2025/04/01
Daily variance  Circadian  Muscle strength  Metabolic benefits  Resistance exercise  
Discovery of novel Bis-amide analogue ST12 for the treatment of inflammatory bowel diseases (IBD) by inhibiting NLRP3 inflammasome activation 期刊论文
BIOORGANIC CHEMISTRY, 2025, 卷号: 159, 页码: 14
作者:  Sun, Zhiqiang;  Zang, Qinru;  Xu, Chenglong;  Zhang, Xuewen;  Kang, Zhenghui;  Yang, Yushe;  Li, Ling;  Chen, Jianjun
收藏  |  浏览/下载：7/0  |  提交时间：2025/05/27
Anti-inflammatory agents  Nitric oxide (NO)  NLRP3 inflammasome  Inflammatory bowel diseases (IBD)  
De Novo Design of Structure-Tunable Multivalent Targeting Chimeras for Tumor-Targeted PD-L1 Degradation and Potentiated Cancer Immunotherapy 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 17
作者:  Zhou, Huiling;  Hou, Bo;  Shan, Yiming;  Huang, Lujia;  Chen, Fangmin;  Ren, Siyuan;  Zhang, Shunan;  Pan, Jiaxing;  Dang, Yijing;  Yu, Haijun;  Xu, Zhiai
收藏  |  浏览/下载：3/0  |  提交时间：2025/06/23
Combinatory therapy, Immune checkpoint blockade, Multivalent targeting chimeras  Tumor microenvironment  Tumor-specific PD-L1 degradation  
"Targeting AhR suppresses hepatocyte ferroptosis in MASH by regulating the Pten/Akt/β catenin axis" [Biochem. Pharmacol. 232 (2025) 116711] 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2025, 卷号: 235, 页码: 1
作者:  Ma, Chenhui;  Han, Li;  Zhao, Wenxuan;  Chen, Feihong;  Huang, Ruimin;  Pang, Cheng Heng;  Zhu, Zheying;  Pan, Guoyu
收藏  |  浏览/下载：10/0  |  提交时间：2025/04/24
Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Patients With Mild or Moderate Hepatic Impairment Versus Participants With Normal Hepatic Function: A Phase I Study 期刊论文
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 7
作者:  Zhou, Jing;  Zhang, Hong;  Ding, Yanhua;  Wang, Zhen;  Wang, Yu;  Juan, Jiaxiang;  Jiang, Zhicheng;  Chen, Hong
收藏  |  浏览/下载：1/0  |  提交时间：2025/06/23
hepatic impairment  pharmacokinetics  phosphodiesterase-5 inhibitor  TPN171  
Proteome-Wide Data Guides the Discovery of Lysine-Targeting Covalent Inhibitors Using DNA-Encoded Chemical Libraries 期刊论文
ANGEWANDTE CHEMIE-INTERNATIONAL EDITION, 2025, 页码: 14
作者:  Wu, Xinyuan;  Li, Shunyao;  Liang, Ting;  Yu, Qing;  Zhang, Yiwei;  Liu, Jiaxiang;  Li, Kaige;  Liu, Zijian;  Cui, Mengqing;  Zhao, Yongchao;  Han, Xin;  Jin, Rui;  Tan, Minjia;  Chen, Xiao-Hua;  Zhao, Yujun;  Zheng, Mingyue;  Sun, Yi;  Zhou, Lu;  Lu, Xiaojie
收藏  |  浏览/下载：4/0  |  提交时间：2025/06/23
Activity-based protein profiling data  Covalent DNA-encoded chemical library  Covalent ligand selection  Lysine-targeting covalent inhibitors  
A Phase I Study to Evaluate the Pharmacokinetics and Safety of TPN171 (a PDE5 Inhibitor) in Adults with Renal Impairment 期刊论文
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT, 2025, 页码: 8
作者:  Fu, Ping;  Song, Yi;  Hu, Chao;  Yong, Xiaolan;  Yu, Yang;  Chen, Yi;  Wang, Ying;  Zhu, Xiaohong;  Wang, Zhen;  Wang, Yu;  Juan, Jiaxiang;  Chen, Yuan;  Miao, Jia
收藏  |  浏览/下载：2/0  |  提交时间：2025/06/23
pharmacokinetics  phosphodiesterase 5 inhibitor  renal impairment  safety  TPN171  
Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types 期刊论文
ISCIENCE, 2025, 卷号: 28, 期号: 4, 页码: 21
作者:  Cai, Xunhui;  Cho, Jennifer Y.;  Chen, Lijun;  Liu, Yufeng;  Ji, Fenghu;  Salgado, Katia;  Ge, Siyi;  Yang, Dehua;  Yu, Hui;  Shao, Jianbo;  Futreal, P. Andrew;  Sepesi, Boris;  Gibbons, Don;  Chen, Yaobing;  Wang, Guoping;  Cheng, Chao;  Wu, Meng;  Zhang, Jianjun;  Hsiao, Ansel;  Xia, Tian
收藏  |  浏览/下载：5/0  |  提交时间：2025/05/27
Proteogenomic characterization of non-functional clinically relevant subgroups 期刊论文
CANCER CELL, 2025, 卷号: 43, 期号: 4, 页码: 36
作者:  Ji, Shunrong;  Cao, Lihua;  Gao, Jing;  Du, Yang;  Ye, Zeng;  Lou, Xin;  Liu, Fen;  Zhang, Yehan;  Xu, Junfeng;  Shi, Xiaohan;  Wang, Huan;  Li, Penghao;  Li, Yikai;  Chen, Hongxu;  Yang, Zhicheng;  Gao, Suizhi;  Zhang, Wuhu;  Huang, Dan;  Ni, Shujuan;  Wei, Miaoyan;  Wang, Fei;  Wang, Yan;  Ding, Tian;  Jing, Desheng;  Fan, Guixiong;  Gong, Zhiyun;  Lu, Renquan;  Qin, Yi;  Chen, Jie;  Xu, Xiaowu;  Wang, Pei;  Zhang, Bing;  Ding, Li;  Robles, Ana I.;  Rodriguez, Henry;  Chang, David K.;  Hruban, Ralph H.;  Gao, Dong;  Gao, Daming;  Jin, Gang;  Zhou, Hu;  Wu, Jianmin;  Yu, Xianjun
收藏  |  浏览/下载：3/0  |  提交时间：2025/06/23
Comparative Study on Covalent and Noncovalent Endogenous Albumin-Binding β-Glucuronidase-Activated SN38 Prodrugs for Antitumor Efficacy 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 8, 页码: 8361-8376
作者:  Lu, Yingxin;  Jiang, Xing;  Yang, Biyu;  Ding, Mengyuan;  Shen, Yanyan;  Jin, Jiyu;  Yu, Jiahui;  Lu, Wei;  Chen, Yi;  Zhu, Shulei
收藏  |  浏览/下载：6/0  |  提交时间：2025/05/27
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