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A novel cocrystal of indole-3-propionic acid and nicotinamide: Structure design, preparation, characterization and preliminary physiochemical properties evaluation 期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2025, 卷号: 1322, 页码: 9
作者:  Guo, Jiacheng;  Xu, Lingling;  You, Wen;  Ji, Yuze;  Chen, Dongying
收藏  |  浏览/下载：148/0  |  提交时间：2024/12/25
Indole-3-propionic acid  Nicotinamide  Cocrystal  Solubility  Permeability  Stability  
Design of Selective BRD4 Inhibitors for the Treatment of Autosomal Dominant Polycystic Kidney Disease 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 18
作者:  Yang, Yueyue;  Liu, Hongli;  Yuan, Haoxing;  Lyu, Kaikai;  Zhong, Haiyang;  Li, Yanlian;  Cao, Danyan;  Zhao, Wenchao;  Zhang, Haoran;  Xiong, Bing;  Chen, Danqi;  Guo, Dong
收藏  |  浏览/下载：12/0  |  提交时间：2025/04/01
Targeting Mesothelin Enhances Personalized Neoantigen Vaccine Induced Antitumor Immune Response in Orthotopic Pancreatic Cancer Mouse Models 期刊论文
ADVANCED SCIENCE, 2025, 页码: 17
作者:  Cai, Zhixiong;  Li, Zhenli;  Zhong, Wenting;  Lin, Fangzhou;  Dong, Xiuqing;  Ye, Honghao;  Guo, Yutong;  Chen, Geng;  Yu, Xiaoling;  Yu, Haijun;  Tang, Ruijing;  Liu, Xiaolong
收藏  |  浏览/下载：15/0  |  提交时间：2025/04/01
apCAFs  immunotherapy  mesothelin  neoantigen vaccine  pancreatic cancer  
Structure-Based Rational Design and Evaluation of BET-Aurora Kinase Dual-Inhibitors for Treatment of Cancers 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21
作者:  Lyu, Kaikai;  Ren, Ying;  Mou, Jie;  Yang, Yunfang;  Pan, Yaoyao;  Zhang, Huijie;  Li, Yanlian;  Cao, Danyan;  Chen, Lin;  Chen, Danqi;  Guo, Dong;  Xiong, Bing
收藏  |  浏览/下载：44/0  |  提交时间：2025/02/28
π-HuB: the proteomic navigator of the human body 期刊论文
NATURE, 2024, 卷号: 636, 期号: 8042, 页码: 322-331
作者:  He, Fuchu;  Aebersold, Ruedi;  Baker, Mark S.;  Bian, Xiuwu;  Bo, Xiaochen;  Chan, Daniel W.;  Chang, Cheng;  Chen, Luonan;  Chen, Xiangmei;  Chen, Yu-Ju;  Cheng, Heping;  Collins, Ben C.;  Corrales, Fernando;  Cox, Juergen;  Weinan, E.;  Van Eyk, Jennifer E.;  Fan, Jia;  Faridi, Pouya;  Figeys, Daniel;  Gao, George Fu;  Gao, Wen;  Gao, Zu-Hua;  Goda, Keisuke;  Goh, Wilson Wen Bin;  Gu, Dongfeng;  Guo, Changjiang;  Guo, Tiannan;  He, Yuezhong;  Heck, Albert J. R.;  Hermjakob, Henning;  Hunter, Tony;  Iyer, Narayanan Gopalakrishna;  Jiang, Ying;  Jimenez, Connie R.;  Joshi, Lokesh;  Kelleher, Neil L.;  Li, Ming;  Li, Yang;  Lin, Qingsong;  Liu, Cui Hua;  Liu, Fan;  Liu, Guang-Hui;  Liu, Yansheng;  Liu, Zhihua;  Low, Teck Yew;  Lu, Ben;  Mann, Matthias;  Meng, Anming;  Moritz, Robert L.;  Nice, Edouard;  Ning, Guang;  Omenn, Gilbert S.;  Overall, Christopher M.;  Palmisano, Giuseppe;  Peng, Yaojin;  Pineau, Charles;  Poon, Terence Chuen Wai;  Purcell, Anthony W.;  Qiao, Jie;  Reddel, Roger R.;  Robinson, Phillip J.;  Roncada, Paola;  Sander, Chris;  Sha, Jiahao;  Song, Erwei;  Srivastava, Sanjeeva;  Sun, Aihua;  Sze, Siu Kwan;  Tang, Chao;  Tang, Liujun;  Tian, Ruijun;  Vizcaino, Juan Antonio;  Wang, Chanjuan;  Wang, Chen;  Wang, Xiaowen;  Wang, Xinxing;  Wang, Yan;  Weiss, Tobias;  Wilhelm, Mathias;  Winkler, Robert;  Wollscheid, Bernd;  Wong, Limsoon;  Xie, Linhai;  Xie, Wei;  Xu, Tao;  Xu, Tianhao;  Yan, Liying;  Yang, Jing;  Yang, Xiao;  Yates, John;  Yun, Tao;  Zhai, Qiwei;  Zhang, Bing;  Zhang, Hui;  Zhang, Lihua;  Zhang, Lingqiang;  Zhang, Pingwen;  Zhang, Yukui;  Zheng, Yu Zi;  Zhong, Qing;  Zhu, Yunping;  Tan, Chris Soon Heng;  Gao, Mingxia;  Gao, Qiang;  Gao, Yushun;  Guo, Xuejiang;  He, Jie;  He, Jun;  He, Qing-Yu;  Hou, Jinlin;  Huang, Canhua;  Jia, Chenxi;  Kuster, Bernhard;  Li, Chaoying;  Li, Dong;  Li, Yanchang;  Liu, Siqi;  Liu, Xiaonan;  Liu, Ya;  Liu, Zhongyang;  Lu, Haojie;  Nie, Yongzhan;  Okada, Mariko;  Qian, Guojun;  Qin, Hongqiang;  Rao, Yu;  Rao, Zihe;  Ren, Xianwen;  Ren, Yan;  Shen, Feng;  Shen, Lin;  Su, Shicheng;  Tan, Minjia;  Tang, Ben Zhong;  Tao, Sheng-Ce;  Wang, Jian;  Wang, Tong;  Wei, Liming;  Wong, Catherine C. L.;  Xie, Xiaoliang Sunney;  Xu, Li;  Xu, Ping;  Yang, Huanming;  Yang, Jianjun;  Ye, Mingliang;  Ying, Wantao;  Yu, Xiaobo;  Yuan, Yaxiang;  Zeng, Qingcun;  Zhan, Qimin;  Zhang, Xiaofei;  Zhang, Xu;  Zhang, Ying;  Zhong, Nan-Shan;  Zhou, Feng;  Zhu, Yi;  Zhang, Zemin
收藏  |  浏览/下载：14/0  |  提交时间：2025/04/01
A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands 期刊论文
NATURE METHODS, 2024, 页码: 17
作者:  Li, Kejia;  Chen, Shijie;  Wang, Keyun;  Wang, Yan;  Xue, Lianji;  Ye, Yuying;  Fang, Zheng;  Lyu, Jiawen;  Zhu, Haiyang;  Li, Yanan;  Yu, Ting;  Yang, Feng;  Zhang, Xiaolei;  Guo, Siqi;  Ruan, Chengfei;  Zhou, Jiahua;  Wang, Qi;  Dong, Mingming;  Luo, Cheng;  Ye, Mingliang
收藏  |  浏览/下载：157/0  |  提交时间：2025/01/14
Molecular insights into the activation mechanism of GPR156 in maintaining auditory function 期刊论文
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 16
作者:  Ma, Xiangyu;  Chen, Li-Nan;  Liao, Menghui;  Zhang, Liyan;  Xi, Kun;  Guo, Jiamin;  Shen, Cangsong;  Shen, Dan-Dan;  Cai, Pengjun;  Shen, Qingya;  Qi, Jieyu;  Zhang, Huibing;  Zang, Shao-Kun;  Dong, Ying-Jun;  Miao, Luwei;  Qin, Jiao;  Ji, Su-Yu;  Li, Yue;  Liu, Jianfeng;  Mao, Chunyou;  Zhang, Yan;  Chai, Renjie
收藏  |  浏览/下载：144/0  |  提交时间：2025/01/14
Optimization and Biological Evaluation of Novel 1H-Pyrrolo[2,3-c]pyridin Derivatives as Potent and Reversible Lysine Specific Demethylase 1 Inhibitors for the Treatment of Acute Myelogenous Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 24, 页码: 22080-22103
作者:  Jiang, Hong;  Li, Cong;  Li, Na;  Sheng, Li;  Wang, Jingkai;  Kan, Wei-Juan;  Chen, Yuelei;  Zhao, Dongmei;  Guo, Dong;  Zhou, Yu-Bo;  Xiong, Bing;  Li, Jia;  Liu, Tongchao
收藏  |  浏览/下载：30/0  |  提交时间：2025/01/14
Shape and Size Dependence of Pharmacokinetics, Biodistribution, and Toxicity of Gold Nanoparticles 期刊论文
MOLECULAR PHARMACEUTICS, 2024, 页码: 13
作者:  Wu, Huaping;  Tang, Lin;  Dong, Huanhuan;  Zhi, Maoxin;  Guo, Liqiong;  Hong, Xuechuan;  Liu, Mingzhe;  Xiao, Yuling;  Zeng, Xiaodong
收藏  |  浏览/下载：49/0  |  提交时间：2025/01/06
gold nanoparticles  nanoparticle morphology  toxicity assessment  biodistribution  pharmacokinetics  
Synergistic immune augmentation enabled by covalently conjugating TLR4 and NOD2 agonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 278, 页码: 15
作者:  Ding, Dong;  Gao, Runing;  Lei, Yujuan;  Liu, Jianing;  Zhou, Chengkai;  Wen, Yu;  Zhou, Shihao;  Guo, Jun;  Li, Tiehai
收藏  |  浏览/下载：67/0  |  提交时间：2024/10/21
TLR4 agonist  NOD2 agonist  Adjuvant  Covalent conjugation  Subunit vaccine  
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