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Self-Oxygenating PROTAC Microneedle for Spatiotemporally-Confined Protein Degradation and Enhanced Glioblastoma Therapy 期刊论文
ADVANCED MATERIALS, 2025, 页码: 13
作者:  Jiang, Xingyu;  Lai, Yi;  Xia, Wenzheng;  Yang, Wenfang;  Wang, Junjue;  Pan, Jiaxing;  Zhao, Qian;  Zhou, Feng;  Li, Shiqin;  Zhang, Shunan;  Gao, Jing;  Wang, Yinyan;  Zan, Tao;  Xu, Zhi Ping;  Yu, Haijun;  Xu, Zhiai
收藏  |  浏览/下载：16/0  |  提交时间：2025/04/24
acid-activatable photodynamic therapy  double-layered microneedle  glioblastoma therapy  light-activatable PROTAC prodrug  protein degradation  
A region-confined PROTAC nanoplatform for spatiotemporally tunable protein degradation and enhanced cancer therapy 期刊论文
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 18
作者:  Gao, Jing;  Jiang, Xingyu;  Lei, Shumin;  Cheng, Wenhao;  Lai, Yi;  Li, Min;  Yang, Lei;  Liu, Peifeng;  Chen, Xiao-hua;  Huang, Min;  Yu, Haijun;  Xu, Huixiong;  Xu, Zhiai
收藏  |  浏览/下载：28/0  |  提交时间：2024/09/26
PROTAC Prodrug-Integrated Nanosensitizer for Potentiating Radiation Therapy of Cancer 期刊论文
ADVANCED MATERIALS, 2024, 页码: 12
作者:  Zhang, Shunan;  Lai, Yi;  Pan, Jiaxing;  Saeed, Madiha;  Li, Shiqin;  Zhou, Huiling;  Jiang, Xingyu;  Gao, Jing;  Zhu, Yun;  Yu, Haijun;  Zhang, Wen;  Xu, Zhiai
收藏  |  浏览/下载：108/0  |  提交时间：2024/04/09
active tumor targeting  nanosensitizer  PROTAC prodrug  radiation therapy  tumor microenvironment  
Discovery, structural optimization, and anti-tumor bioactivity evaluations of betulinic acid derivatives as a new type of ROR & gamma; antagonists 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 257, 页码: 15
作者:  Mei, Lianghe;  Xu, Lansong;  Wu, Sanan;  Wang, Yafang;  Xu, Chao;  Wang, Lin;  Zhang, Xingyu;  Yu, Chengcheng;  Jiang, Hualiang;  Zhang, Xianglei;  Bai, Fang;  Xie, Chengying
收藏  |  浏览/下载：105/0  |  提交时间：2023/10/17
Betulinic acid  ROR & gamma  Target identification  Rationale structure optimization  Anti-tumor effects  antagonists  
A comprehensive analysis of the Bencao (herbal) small RNA Atlas reveals novel RNA therapeutics for treating human diseases 期刊论文
SCIENCE CHINA-LIFE SCIENCES, 2023, 页码: 19
作者:  Cao, Yinghao;  Lin, Yexuan;  Sun, Na;  Du, Xinyi;  Dong, Yixin;  Mei, Song;  Deng, Xingyu;  Li, Xiaobei;  Guo, Shaoting;  Tang, Kegong;  Liu, Jiaqi;  Qiao, Xiangyu;  Zhao, Dandan;  Qin, Yuhao;  Zhang, Cong;  Xin, Tianyi;  Shi, Xiaohu;  Zhou, Congzhao;  Dong, Tao;  Guo, De-an;  Kessler, Benedikt M.;  Xu, Dong;  Song, Jingyuan;  Huang, Fengming;  Wang, Xiaoyue;  Jiang, Chengyu
收藏  |  浏览/下载：91/0  |  提交时间：2023/10/17
small RNA  herbal decoction  cross-kingdom regulation  traditional Chinese medicine  RNA oligonucleotide drug  RNA therapeutics  Bencao small RNA Atlas  
Engineered bioorthogonal POLY-PROTAC nanoparticles for tumour-specific protein degradation and precise cancer therapy 期刊论文
NATURE COMMUNICATIONS, 2022, 卷号: 13, 期号: 1, 页码: 14
作者:  Gao, Jing;  Hou, Bo;  Zhu, Qiwen;  Yang, Lei;  Jiang, Xingyu;  Zou, Zhifeng;  Li, Xutong;  Xu, Tianfeng;  Zheng, Mingyue;  Chen, Yi-Hung;  Xu, Zhiai;  Xu, Huixiong;  Yu, Haijun
收藏  |  浏览/下载：63/0  |  提交时间：2022/08/30
One-Step Microfluidic Synthesis of Nanocomplex with Tunable Rigidity and Acid-Switchable Surface Charge for Overcoming Drug Resistance 期刊论文
SMALL, 2017, 卷号: 13, 期号: 9
作者:  Feng, Qiang;  Liu, Jianping;  Li, Xuanyu;  Chen, Qinghua;  Sun, Jiashu;  Shi, Xinghua;  Ding, Baoquan;  Yu, Haijun;  Li, Yaping;  Jiang, Xingyu
收藏  |  浏览/下载：48/0  |  提交时间：2019/01/08
Thymine DNA glycosylase specifically recognizes 5-carboxylcytosine-modified DNA 期刊论文
NATURE CHEMICAL BIOLOGY, 2012, 卷号: 8, 期号: 4, 页码: 328-330
作者:  Zhang, Liang;  Lu, Xingyu;  Lu, Junyan;  Liang, Haihua;  Dai, Qing;  Xu, Guo-Liang;  Luo, Cheng;  Jiang, Hualiang;  He, Chuan
收藏  |  浏览/下载：44/0  |  提交时间：2019/01/08
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