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Discovery of a potential hematologic malignancies therapy: Selective and potent HDAC7 PROTAC degrader targeting non-enzymatic function 期刊论文
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 3, 页码: 1659-1679
作者:  Jin, Yuheng;  Qi, Xuxin;  Yu, Xiaoli;  Cheng, Xirui;  Chen, Boya;  Wu, Mingfei;  Zhang, Jingyu;  Yin, Hao;  Lu, Yang;  Zhou, Yihui;  Pang, Ao;  Lin, Yushen;  Jiang, Li;  Shi, Qiuqiu;  Geng, Shuangshuang;  Zhou, Yubo;  Yao, Xiaojun;  Li, Linjie;  Duan, Haiting;  Che, Jinxin;  Cao, Ji;  He, Qiaojun;  Dong, Xiaowu
收藏  |  浏览/下载：1/0  |  提交时间：2025/06/23
HDAC7  PROTAC  Selectivity  Hematologic malignancies  Non-enzymatic function  
Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 15
作者:  Chen, Jiexuan;  Wu, Mingfei;  Mo, Jun;  Hong, Ju;  Wang, Wei;  Jin, Yuheng;  Mao, Xinfei;  Liao, Xueyan;  Li, Kailin;  Yu, Xiaoli;  Chen, Sikang;  Zeng, Shenxin;  Huang, Wenhai;  Xu, Hongxia;  Wu, Jian;  Cao, Ji;  Zhou, Yubo;  Ying, Meidan;  Zhu, Chengliang;  He, Qiaojun;  Zhang, Bo;  Lin, Nengming;  Dong, Xiaowu;  Che, Jinxin
收藏  |  浏览/下载：20/0  |  提交时间：2025/04/01
Structure-based identification of new orally bioavailable BRD9-PROTACs for treating acute myelocytic leukemia 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2023, 卷号: 262, 页码: 18
作者:  Zhang, Jingyu;  Duan, Haiting;  Gui, Renzhao;  Wu, Mingfei;  Shen, Liteng;  Jin, Yuheng;  Pang, Ao;  Yu, Xiaoli;  Zeng, Shenxin;  Zhang, Bo;  Lin, Nengming;  Huang, Wenhai;  Wang, Yuwei;  Yao, Xiaojun;  Li, Jia;  Dong, Xiaowu;  Zhou, Yubo;  Che, Jinxin
收藏  |  浏览/下载：77/0  |  提交时间：2023/12/19
Acute myeloid leukemia  Bromodomain-containing protein 9  Proteolysis-targeting chimera  Orally bioavailable  Docking  
Structural Feature Analyzation Strategies toward Discovery of Orally Bioavailable PROTACs of Bruton's Tyrosine Kinase for the Treatment of Lymphoma 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2022, 卷号: 65, 期号: 13, 页码: 9096–9125
作者:  Zhang, Jingyu;  Che, Jinxin;  Luo, Xiaomin;  Wu, Mingfei;  Kan, Weijuan;  Jin, Yuheng;  Wang, Hanlin;  Pang, Ao;  Li, Cong;  Huang, Wenhai;  Zeng, Shenxin;  Zhuang, Weihao;  Wu, Yizhe;  Xu, Yongjin;  Zhou, Yubo;  Li, Jia;  Dong, Xiaowu
收藏  |  浏览/下载：49/0  |  提交时间：2024/03/21
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