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Harnessing the Magic Methyl Effect: Discovery of CLPP-2068 as a Novel HsClpP Activator for the Treatment of Diffuse Large B-Cell Lymphoma 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 68, 期号: 4, 页码: 4287-4307
Authors:  Sun, Mingyang;  Chen, Beijing;  Teng, Dan;  Zhao, Hongshen;  Liao, Yilie;  Zhang, Chun;  Huang, Qi;  Ma, Huicong;  Wang, Chongyu;  Lin, Xinyi;  Yu, Peng;  Yuan, Qingning;  Yu, Jinghua;  Xu, Lei;  Hu, Xiaobei;  Ye, Fei;  Diao, Xingxing;  Zheng, Mingyue;  Yin, Wanchao;  Zhou, Yubo;  Li, Jia;  Wang, Mingliang
Favorite  |  View/Download：7/0  |  Submit date：2025/04/01
Gentiopicroside ameliorates psoriasis-like skin lesions in mice via regulating the Keap1-Nrf2 pathway and inhibiting keratinocyte activation 期刊论文
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 14
Authors:  Ren, Jing;  Chen, Xin;  Wang, Hao-yu;  Yang, Tao;  Zhang, Kai-rong;  Lei, Shu-yue;  Qi, Lu-yao;  Feng, Chun-lan;  Zhou, Rong;  Zhou, Hu;  Tang, Wei
Favorite  |  View/Download：11/0  |  Submit date：2025/04/01
psoriasis  gentiopicroside  keratinocyte  oxidative stress  Keap1-Nrf2 pathway  calcipotriol  
Discovery of CLPP-1071 as an Exceptionally Potent and Orally Efficacious Human ClpP Activator with Strong In Vivo Antitumor Activity 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 21
Authors:  Chen, Beijing;  Sun, Mingyang;  Zhang, Chun;  Huang, Qi;  Teng, Dan;  Hu, Linghao;  Ma, Huicong;  Lin, Xinyi;  Huang, Zan;  Gui, Renzhao;  Hu, Xiaobei;  Xu, Lei;  Zheng, Mingyue;  Zhou, Yubo;  Li, Jia;  Wang, Mingliang
Favorite  |  View/Download：65/0  |  Submit date：2024/12/25
RIPK1 inhibitor ameliorates pulmonary injury by modulating the function of neutrophils and vascular endothelial cells 期刊论文
CELL DEATH DISCOVERY, 2024, 卷号: 10, 期号: 1, 页码: 12
Authors:  Yang, Tao;  Xiang, Cai-gui;  Wang, Xiao-han;  Li, Qing-qing;  Lei, Shu-yue;  Zhang, Kai-rong;  Ren, Jing;  Lu, Hui-min;  Feng, Chun-lan;  Tang, Wei
Favorite  |  View/Download：49/0  |  Submit date：2024/05/07
Formyl phloroglucinol meroterpenoids from the leaves of Eucalyptus globulus subsp. maidenii and their ATP-citrate lyase inhibitory activities 期刊论文
FITOTERAPIA, 2024, 卷号: 173, 页码: 6
Authors:  Hu, Zhu;  Liu, Yi-Nan;  Yu, Mei-Hua;  Hou, Ai -Jun;  Li, Jing-Ya;  Li, Ying-Xia;  Lei, Chun
Favorite  |  View/Download：38/0  |  Submit date：2024/03/13
Eucalyptus globulus subsp. maidenii  Meroterpenoids  ATP-citrate lyase  
Design, synthesis and biological evaluation of betulinic acid derivatives as potential inhibitors of 3CL-protease of SARS-CoV-2 期刊论文
STEROIDS, 2024, 卷号: 202, 页码: 8
Authors:  Liu, Yaowen;  Nie, Tianqing;  Hou, Jinjun;  Long, Huali;  Zhang, Zijia;  Lei, Min;  Xu, Yechun;  Wu, Wanying
Favorite  |  View/Download：60/0  |  Submit date：2024/03/13
3CLpro  SARS-CoV-2  Betulinic acid  Natural product  Inhibitory activity  
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects 期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
Authors:  Yang, Xin-Mei;  Yang, Yang;  Yao, Bu-Fan;  Ye, Pan-Pan;  Xu, Yan;  Peng, Shao-Ping;  Yang, Yu-Mei;  Shu, Pan;  Li, Pei-Jin;  Li, Shan;  Hu, Hong-Lin;  Li, Qian;  Song, Lin-Lin;  Chen, Ke-Guang;  Zhou, Hai-Yan;  Zhang, Ye-Hui;  Zhao, Fu-Rong;  Tang, Bo-Hao;  Zhang, Wei;  Zhang, Xin-Fang;  Fu, Shu-Meng;  Hao, Guo-Xiang;  Zheng, Yi;  Shen, Jing-Shan;  Xu, Ye-Chun;  Jiang, Xiang-Rui;  Zhang, Lei-Ke;  Tang, Ren-Hong;  Zhao, Wei
Favorite  |  View/Download：68/0  |  Submit date：2023/12/11
COVID-19  Simnotrelvir  Safety  Pharmacokinetics  Healthy subjects  
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir 期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15
Authors:  Jiang, Xiangrui;  Su, Haixia;  Shang, Weijuan;  Zhou, Feng;  Zhang, Yan;  Zhao, Wenfeng;  Zhang, Qiumeng;  Xie, Hang;  Jiang, Lei;  Nie, Tianqing;  Yang, Feipu;  Xiong, Muya;  Huang, Xiaoxing;  Li, Minjun;  Chen, Ping;  Peng, Shaoping;  Xiao, Gengfu;  Jiang, Hualiang;  Tang, Renhong;  Zhang, Leike;  Shen, Jingshan;  Xu, Yechun
Favorite  |  View/Download：46/0  |  Submit date：2024/03/25
Elucidation of N-/O-glycosylation and site-specific mapping of sialic acid linkage isomers of SARS-CoV-2 human receptor angiotensin-converting enzyme 2 期刊论文
ANALYST, 2023, 卷号: 148, 期号: 20, 页码: 5002-5011
Authors:  Wei, Liming;  Chen, Yuning;  Feng, Xiaoxiao;  Yao, Jun;  Zhang, Lei;  Zhou, Xinwen;  Yan, Guoquan;  Qiu, Hong;  Wang, Chunhe;  Lu, Haojie
Favorite  |  View/Download：55/0  |  Submit date：2023/12/08
Novel thieno[2,3-b]quinoline-procaine hybrid molecules: A new class of allosteric SHP-1 activators evolved from PTP1B inhibitors 期刊论文
CHINESE CHEMICAL LETTERS, 2023, 卷号: 34, 期号: 8, 页码: 6
Authors:  Xu, Lei;  Xuyan, Xuyang;  Minmi, Minmin;  Wang, Zhiji;  Shee, Chao;  Mu, Qianwen;  Feng, Bo;  Xu, Yechun;  Hou, Tingjun;  Gao, Lixin;  Jiang, Haini;  Li, Jia;  Zhou, Yubo;  Wang, Wenlong
Favorite  |  View/Download：68/0  |  Submit date：2023/10/17
Activator  PTPs  Inhibitor  Thieno[2  b ]quinoline derivatives  Diffuse large B-cell lymphoma  
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