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Bicyclic polyprenylated acylphloroglucinol-related meroterpenoids as potent DRAK2 inhibitors from Hypericum patulum 期刊论文
PHYTOCHEMISTRY, 2025, 卷号: 232, 页码: 10
Authors:  Huang, Jin-Chang;  Jia, Xin-Yu;  Lv, Yi-Fan;  Xu, Hong-Hong;  Han, Ming;  Yu, Qiang-Qiang;  Lu, Yu-Ting;  Yang, Hong-Xun;  Yang, Yang;  Li, Jing-Ya;  Hou, Ai-Jun
Favorite  |  View/Download：9/0  |  Submit date：2025/04/01
Hypericum patulum  Hypericaceae  Meroterpenoids  Hyperpatins A-H  Death-associated protein kinase-related  apoptosis-inducing kinase 2  Glucose-stimulated insulin secretion  
A Phase I Study to Evaluate the Safety, Tolerability, Pharmacokinetics of BGT-002, a Novel ATP-Citrate Lyase Inhibitor, in Healthy Chinese Subjects 期刊论文
DRUG DESIGN DEVELOPMENT AND THERAPY, 2025, 卷号: 19, 页码: 1783-1794
Authors:  Liu, Yun;  Yu, Chengyin;  Zhang, Yifan;  Xie, Zhifu;  Wang, Yating;  Qian, Hongjie;  Liang, Liyu;  Liu, Yanmei;  Chen, Qian;  Jia, Jingying;  Yan, Sai;  Lai, Xiaoyin;  Li, Wei;  Li, Jingya;  Zhang, Yangming;  Nan, Fajun;  Yu, Chen
Favorite  |  View/Download：27/0  |  Submit date：2025/04/24
safety  tolerability  pharmacokinetics  pharmacodynamics  BGT-002  novel ACLY inhibitor  
π-HuB: the proteomic navigator of the human body 期刊论文
NATURE, 2024, 卷号: 636, 期号: 8042, 页码: 322-331
Authors:  He, Fuchu;  Aebersold, Ruedi;  Baker, Mark S.;  Bian, Xiuwu;  Bo, Xiaochen;  Chan, Daniel W.;  Chang, Cheng;  Chen, Luonan;  Chen, Xiangmei;  Chen, Yu-Ju;  Cheng, Heping;  Collins, Ben C.;  Corrales, Fernando;  Cox, Juergen;  Weinan, E.;  Van Eyk, Jennifer E.;  Fan, Jia;  Faridi, Pouya;  Figeys, Daniel;  Gao, George Fu;  Gao, Wen;  Gao, Zu-Hua;  Goda, Keisuke;  Goh, Wilson Wen Bin;  Gu, Dongfeng;  Guo, Changjiang;  Guo, Tiannan;  He, Yuezhong;  Heck, Albert J. R.;  Hermjakob, Henning;  Hunter, Tony;  Iyer, Narayanan Gopalakrishna;  Jiang, Ying;  Jimenez, Connie R.;  Joshi, Lokesh;  Kelleher, Neil L.;  Li, Ming;  Li, Yang;  Lin, Qingsong;  Liu, Cui Hua;  Liu, Fan;  Liu, Guang-Hui;  Liu, Yansheng;  Liu, Zhihua;  Low, Teck Yew;  Lu, Ben;  Mann, Matthias;  Meng, Anming;  Moritz, Robert L.;  Nice, Edouard;  Ning, Guang;  Omenn, Gilbert S.;  Overall, Christopher M.;  Palmisano, Giuseppe;  Peng, Yaojin;  Pineau, Charles;  Poon, Terence Chuen Wai;  Purcell, Anthony W.;  Qiao, Jie;  Reddel, Roger R.;  Robinson, Phillip J.;  Roncada, Paola;  Sander, Chris;  Sha, Jiahao;  Song, Erwei;  Srivastava, Sanjeeva;  Sun, Aihua;  Sze, Siu Kwan;  Tang, Chao;  Tang, Liujun;  Tian, Ruijun;  Vizcaino, Juan Antonio;  Wang, Chanjuan;  Wang, Chen;  Wang, Xiaowen;  Wang, Xinxing;  Wang, Yan;  Weiss, Tobias;  Wilhelm, Mathias;  Winkler, Robert;  Wollscheid, Bernd;  Wong, Limsoon;  Xie, Linhai;  Xie, Wei;  Xu, Tao;  Xu, Tianhao;  Yan, Liying;  Yang, Jing;  Yang, Xiao;  Yates, John;  Yun, Tao;  Zhai, Qiwei;  Zhang, Bing;  Zhang, Hui;  Zhang, Lihua;  Zhang, Lingqiang;  Zhang, Pingwen;  Zhang, Yukui;  Zheng, Yu Zi;  Zhong, Qing;  Zhu, Yunping;  Tan, Chris Soon Heng;  Gao, Mingxia;  Gao, Qiang;  Gao, Yushun;  Guo, Xuejiang;  He, Jie;  He, Jun;  He, Qing-Yu;  Hou, Jinlin;  Huang, Canhua;  Jia, Chenxi;  Kuster, Bernhard;  Li, Chaoying;  Li, Dong;  Li, Yanchang;  Liu, Siqi;  Liu, Xiaonan;  Liu, Ya;  Liu, Zhongyang;  Lu, Haojie;  Nie, Yongzhan;  Okada, Mariko;  Qian, Guojun;  Qin, Hongqiang;  Rao, Yu;  Rao, Zihe;  Ren, Xianwen;  Ren, Yan;  Shen, Feng;  Shen, Lin;  Su, Shicheng;  Tan, Minjia;  Tang, Ben Zhong;  Tao, Sheng-Ce;  Wang, Jian;  Wang, Tong;  Wei, Liming;  Wong, Catherine C. L.;  Xie, Xiaoliang Sunney;  Xu, Li;  Xu, Ping;  Yang, Huanming;  Yang, Jianjun;  Ye, Mingliang;  Ying, Wantao;  Yu, Xiaobo;  Yuan, Yaxiang;  Zeng, Qingcun;  Zhan, Qimin;  Zhang, Xiaofei;  Zhang, Xu;  Zhang, Ying;  Zhong, Nan-Shan;  Zhou, Feng;  Zhu, Yi;  Zhang, Zemin
Favorite  |  View/Download：8/0  |  Submit date：2025/04/01
Discovery of Alkyl Conjugated Diene Diacids as Novel ACLY Inhibitors 期刊论文
CHINESE JOURNAL OF ORGANIC CHEMISTRY, 2024, 卷号: 44, 期号: 11, 页码: 3476-3489
Authors:  Cheng, Tingting;  Song, Gaolei;  Cheng, Long;  Wang, Fan;  Sun, Xinyu;  Xie, Zhifu;  Zhang, Yangming;  Li, Jingya;  Nan, Fajun
Favorite  |  View/Download：16/0  |  Submit date：2025/02/28
metabolic diseases  ATP-citrate lyase (ACLY)  lipogenesis  ACLY inhibitors  dienyldicarboxylic acid  
Potential therapeutic strategies for MASH: from preclinical to clinical development 期刊论文
LIFE METABOLISM, 2024, 卷号: 3, 期号: 5, 页码: loae029
Authors:  Xie, Zhifu;  Li, Yufeng;  Cheng, Long;  Huang, Yidan;  Rao, Wanglin;  Shi, Honglu;  Li, Jingya
Favorite  |  View/Download：3/0  |  Submit date：2025/06/04
steatosis  inflammation  fibrosis  metabolic dysfunction-associated steatohepatitis  pharmacotherapy  
Highly Aromatic Norditerpenoid Heterodimers and Monomers from Trigonostemon fragilis 期刊论文
ENGINEERING, 2024, 卷号: 38, 页码: 144-154
Authors:  Zhou, Jun-Su;  Cheng, Long;  Gao, Yuan;  Ge, Zhan-Peng;  Zhou, Bin;  Li, Jing-Ya;  Zhao, Jin-Xin;  Yue, Jian-Min
Favorite  |  View/Download：24/0  |  Submit date：2024/10/21
Norditerpenoid heterodimer  Trigonostemon fragilis  Euphorbiaceae  Trigofragiloid  Structural revision  Adenosine triphosphate-citrate lyase (ACLY)  inhibitory activity  
Simultaneous determination of BGT-002 and its acyl glucuronide metabolite ZM326E-M2 in human plasma by liquid chromatography-tandem mass spectrometry and its application to a pharmacokinetic study 期刊论文
JOURNAL OF PHARMACEUTICAL AND BIOMEDICAL ANALYSIS, 2024, 卷号: 243, 页码: 8
Authors:  Zhu, Xueran;  Cui, Shumin;  Liu, Xinjing;  Zhang, Mei;  Xie, Zhifu;  Li, Wei;  Li, Jingya;  Nan, Fajun;  Zhang, Yangming;  Zhan, Yan;  Chen, Xiaoyan
Favorite  |  View/Download：64/0  |  Submit date：2024/05/31
ATP-Citrate Lyase  BGT-002  Acyl glucuronide metabolite  Pseudo-MRM  LC-MS/MS  Pharmacokinetics  
Medcheck: a novel software for automated de-formulation of traditional Chinese medicine (TCM) prescriptions by liquid chromatography-mass spectrometry 期刊论文
JOURNAL OF PHARMACEUTICAL ANALYSIS, 2024, 卷号: 14, 期号: 6, 页码: 3
Authors:  Li, Xiao-lan;  Zhang, Jian-qing;  Li, Yun;  Shen, Xuan-jing;  Yang, Huan-ya;  Yang, Lin;  Xu, Meng;  Bi, Qi-rui;  Yao, Chang-liang;  Guo, De-an
Favorite  |  View/Download：29/0  |  Submit date：2024/08/22
Polyphenol Compound 18a Modulates UCP1-Dependent Thermogenesis to Counteract Obesity 期刊论文
BIOMOLECULES, 2024, 卷号: 14, 期号: 6, 页码: 21
Authors:  Wen, Xueping;  Song, Yufei;  Zhang, Mei;  Kang, Yiping;  Chen, Dandan;  Ma, Hui;  Nan, Fajun;  Duan, Yanan;  Li, Jingya
Favorite  |  View/Download：38/0  |  Submit date：2024/08/22
18a  adipocytes  polyphenols  thermogenesis  UCP1  
Hyperlanins A and B, Two Highly Rearranged Meroterpenoids from Hypericum lancasteri 期刊论文
CHINESE JOURNAL OF CHEMISTRY, 2024, 页码: 7
Authors:  You, Jin-Qiu;  Jin, Yun-Qi;  Li, Meng-Yu;  Zhang, Bo-Chao;  Sun, Xin-Yu;  Ding, Chun-Yong;  Li, Jing-Ya;  Hou, Ai-Jun
Favorite  |  View/Download：39/0  |  Submit date：2024/06/27
Natural products  Hypericum lancasteri  Meroterpenoids  Structure elucidation  Inflammation  
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