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Oral FPR2/ALX modulators tune myeloid cell activity to ameliorate mucosal inflammation in inflammatory bowel disease 期刊论文
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 16
作者:  Yang, Wen-sheng;  Liu, Qing;  Li, Yang;  Li, Guan-yi;  Lin, Shi;  Li, Jie;  Li, Lin-yu;  Li, Yuan;  Ge, Xi-lin;  Wang, Xiao-zhen;  Wu, Wei;  Yan, Jun;  Wang, Guang-fei;  Zhou, Qing-tong;  Liu, Qiang;  Wang, Ming-Wei;  Li, Zhi-ping
收藏  |  浏览/下载：20/0  |  提交时间：2025/04/24
IBD  FPR2/ALX  Quin-C1  Quin-C7  neutrophils  macrophages  
CXCR2 modulates chronic pain comorbid depression in mice by regulating adult neurogenesis in the ventral dentate gyrus 期刊论文
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 13
作者:  Li, Xiao-jie;  Wu, Shuo;  Liu, Zi-han;  Liu, An-an;  Peng, Hui-sheng;  Wang, Yu-jun;  Chen, Ye-xiang;  Liu, Jing-gen;  Xu, Chi
收藏  |  浏览/下载：11/0  |  提交时间：2025/04/01
chronic pain comorbid depression  adult neurogenesis  dentate gyrus  CXCR2  Wnt3a/beta-catenin pathway  
Design and development of a series of 4-(piperazin-1-yl)pyrimidines as irreversible menin inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 280, 页码: 20
作者:  Luo, Menglan;  Ye, Yunfei;  Tang, Lu;  Kan, Weijuan;  Chen, Lin;  Li, Cong;  Sheng, Li;  Zhou, Yubo;  Li, Jia;  Xiong, Bing;  Wang, Hanlin;  Chen, Danqi
收藏  |  浏览/下载：53/0  |  提交时间：2024/11/26
Menin  Covalent inhibitor  Antitumor  Degradation  
π-HuB: the proteomic navigator of the human body 期刊论文
NATURE, 2024, 卷号: 636, 期号: 8042, 页码: 322-331
作者:  He, Fuchu;  Aebersold, Ruedi;  Baker, Mark S.;  Bian, Xiuwu;  Bo, Xiaochen;  Chan, Daniel W.;  Chang, Cheng;  Chen, Luonan;  Chen, Xiangmei;  Chen, Yu-Ju;  Cheng, Heping;  Collins, Ben C.;  Corrales, Fernando;  Cox, Juergen;  Weinan, E.;  Van Eyk, Jennifer E.;  Fan, Jia;  Faridi, Pouya;  Figeys, Daniel;  Gao, George Fu;  Gao, Wen;  Gao, Zu-Hua;  Goda, Keisuke;  Goh, Wilson Wen Bin;  Gu, Dongfeng;  Guo, Changjiang;  Guo, Tiannan;  He, Yuezhong;  Heck, Albert J. R.;  Hermjakob, Henning;  Hunter, Tony;  Iyer, Narayanan Gopalakrishna;  Jiang, Ying;  Jimenez, Connie R.;  Joshi, Lokesh;  Kelleher, Neil L.;  Li, Ming;  Li, Yang;  Lin, Qingsong;  Liu, Cui Hua;  Liu, Fan;  Liu, Guang-Hui;  Liu, Yansheng;  Liu, Zhihua;  Low, Teck Yew;  Lu, Ben;  Mann, Matthias;  Meng, Anming;  Moritz, Robert L.;  Nice, Edouard;  Ning, Guang;  Omenn, Gilbert S.;  Overall, Christopher M.;  Palmisano, Giuseppe;  Peng, Yaojin;  Pineau, Charles;  Poon, Terence Chuen Wai;  Purcell, Anthony W.;  Qiao, Jie;  Reddel, Roger R.;  Robinson, Phillip J.;  Roncada, Paola;  Sander, Chris;  Sha, Jiahao;  Song, Erwei;  Srivastava, Sanjeeva;  Sun, Aihua;  Sze, Siu Kwan;  Tang, Chao;  Tang, Liujun;  Tian, Ruijun;  Vizcaino, Juan Antonio;  Wang, Chanjuan;  Wang, Chen;  Wang, Xiaowen;  Wang, Xinxing;  Wang, Yan;  Weiss, Tobias;  Wilhelm, Mathias;  Winkler, Robert;  Wollscheid, Bernd;  Wong, Limsoon;  Xie, Linhai;  Xie, Wei;  Xu, Tao;  Xu, Tianhao;  Yan, Liying;  Yang, Jing;  Yang, Xiao;  Yates, John;  Yun, Tao;  Zhai, Qiwei;  Zhang, Bing;  Zhang, Hui;  Zhang, Lihua;  Zhang, Lingqiang;  Zhang, Pingwen;  Zhang, Yukui;  Zheng, Yu Zi;  Zhong, Qing;  Zhu, Yunping;  Tan, Chris Soon Heng;  Gao, Mingxia;  Gao, Qiang;  Gao, Yushun;  Guo, Xuejiang;  He, Jie;  He, Jun;  He, Qing-Yu;  Hou, Jinlin;  Huang, Canhua;  Jia, Chenxi;  Kuster, Bernhard;  Li, Chaoying;  Li, Dong;  Li, Yanchang;  Liu, Siqi;  Liu, Xiaonan;  Liu, Ya;  Liu, Zhongyang;  Lu, Haojie;  Nie, Yongzhan;  Okada, Mariko;  Qian, Guojun;  Qin, Hongqiang;  Rao, Yu;  Rao, Zihe;  Ren, Xianwen;  Ren, Yan;  Shen, Feng;  Shen, Lin;  Su, Shicheng;  Tan, Minjia;  Tang, Ben Zhong;  Tao, Sheng-Ce;  Wang, Jian;  Wang, Tong;  Wei, Liming;  Wong, Catherine C. L.;  Xie, Xiaoliang Sunney;  Xu, Li;  Xu, Ping;  Yang, Huanming;  Yang, Jianjun;  Ye, Mingliang;  Ying, Wantao;  Yu, Xiaobo;  Yuan, Yaxiang;  Zeng, Qingcun;  Zhan, Qimin;  Zhang, Xiaofei;  Zhang, Xu;  Zhang, Ying;  Zhong, Nan-Shan;  Zhou, Feng;  Zhu, Yi;  Zhang, Zemin
收藏  |  浏览/下载：21/0  |  提交时间：2025/04/01
Optimization and Biological Evaluation of Novel 1H-Pyrrolo[2,3-c]pyridin Derivatives as Potent and Reversible Lysine Specific Demethylase 1 Inhibitors for the Treatment of Acute Myelogenous Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 24, 页码: 22080-22103
作者:  Jiang, Hong;  Li, Cong;  Li, Na;  Sheng, Li;  Wang, Jingkai;  Kan, Wei-Juan;  Chen, Yuelei;  Zhao, Dongmei;  Guo, Dong;  Zhou, Yu-Bo;  Xiong, Bing;  Li, Jia;  Liu, Tongchao
收藏  |  浏览/下载：35/0  |  提交时间：2025/01/14
Structural Basis of Main Proteases of Coronavirus Bound to Bofutrelvir 期刊论文
JOURNAL OF MOLECULAR BIOLOGY, 2024, 卷号: 436, 期号: 22, 页码: 16
作者:  Wang, Wei-wei;  Zeng, Pei;  Liu, Tongchao;  Zhou, Xue-lan;  Lin, Cheng;  Guo, Li;  Wang, Qi-sheng;  Li, Jian
收藏  |  浏览/下载：34/0  |  提交时间：2024/10/21
SARS-CoV-2  Coronavirus  Main protease  Mutants  Inhibitor  
Repurposing endogenous type I-E CRISPR-Cas systems for natural product discovery in Streptomyces 期刊论文
NATURE COMMUNICATIONS, 2024, 卷号: 15, 期号: 1, 页码: 12
作者:  Zhou, Qun;  Zhao, Yatong;  Ke, Changqiang;  Wang, Haojun;  Gao, Sheng;  Li, Hui;  Zhang, Yan;  Ye, Yang;  Luo, Yunzi
收藏  |  浏览/下载：30/0  |  提交时间：2025/04/01
A two-front nutrient supply environment fuels small intestinal physiology through differential regulation of nutrient absorption and host defense 期刊论文
CELL, 2024, 卷号: 187, 期号: 22, 页码: 42
作者:  Zhang, Jian;  Tian, Ruonan;  Liu, Jia;  Yuan, Jie;  Zhang, Siwen;  Chi, Zhexu;  Yu, Weiwei;  Yu, Qianzhou;  Wang, Zhen;  Chen, Sheng;  Li, Mobai;  Yang, Dehang;  Hu, Tianyi;  Deng, Qiqi;  Lu, Xiaoyang;  Yang, Yidong;  Zhou, Rongbin;  Zhang, Xue;  Liu, Wanlu;  Wang, Di
收藏  |  浏览/下载：49/0  |  提交时间：2024/12/11
Structural basis of psychedelic LSD recognition at dopamine D1 receptor 期刊论文
NEURON, 2024, 卷号: 112, 期号: 19, 页码: 25
作者:  Fan, Luyu;  Zhuang, Youwen;  Wu, Hongyu;  Li, Huiqiong;  Xu, Youwei;  Wang, Yue;  He, Licong;  Wang, Shishan;  Chen, Zhangcheng;  Cheng, Jianjun;  Xu, H. Eric;  Wang, Sheng
收藏  |  浏览/下载：48/0  |  提交时间：2024/11/26
Gut microbiota-brain bile acid axis orchestrates aging-related neuroinflammation and behavior impairment in mice 期刊论文
PHARMACOLOGICAL RESEARCH, 2024, 卷号: 208, 页码: 15
作者:  Ma, Junli;  Li, Mingxiao;  Bao, Yiyang;  Huang, Wenjin;  He, Xiaofang;  Hong, Ying;  Wei, Wenjing;  Liu, Zekun;  Gao, Xinxin;  Yang, Yang;  Cui, Zhengyu;  Wang, Wantao;  Wang, Jie;  Zhu, Weize;  Zheng, Ningning;  Pan, Lingyun;  Wang, Deheng;  Ke, Zunji;  Zhou, Ben;  Sheng, Lili;  Li, Houkai
收藏  |  浏览/下载：49/0  |  提交时间：2024/10/21
aging  brain  neuro-impairment  bile acid  gut microbiota  
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