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Gut microbiota-brain bile acid axis orchestrates aging-related neuroinflammation and behavior impairment in mice 期刊论文
PHARMACOLOGICAL RESEARCH, 2024, 卷号: 208, 页码: 15
作者:  Ma, Junli;  Li, Mingxiao;  Bao, Yiyang;  Huang, Wenjin;  He, Xiaofang;  Hong, Ying;  Wei, Wenjing;  Liu, Zekun;  Gao, Xinxin;  Yang, Yang;  Cui, Zhengyu;  Wang, Wantao;  Wang, Jie;  Zhu, Weize;  Zheng, Ningning;  Pan, Lingyun;  Wang, Deheng;  Ke, Zunji;  Zhou, Ben;  Sheng, Lili;  Li, Houkai
收藏  |  浏览/下载：46/0  |  提交时间：2024/10/21
aging  brain  neuro-impairment  bile acid  gut microbiota  
Activation of hepatic adenosine A1 receptor ameliorates MASH via inhibiting SREBPs maturation 期刊论文
CELL REPORTS MEDICINE, 2024, 卷号: 5, 期号: 3, 页码: 25
作者:  Zhu, Weize;  Hong, Ying;  Tong, Zhaowei;  He, Xiaofang;  Li, Yan;  Wang, Hao;  Gao, Xinxin;  Song, Pengtao;  Zhang, Xianshan;  Wu, Xiaochang;  Tan, Zhenhua;  Huang, Wenjin;  Liu, Zekun;  Bao, Yiyang;  Ma, Junli;  Zheng, Ningning;  Xie, Cen;  Ke, Xisong;  Zhou, Wen;  Jia, Wei;  Li, Mingxiao;  Zhong, Jing;  Sheng, Lili;  Li, Houkai
收藏  |  浏览/下载：67/0  |  提交时间：2024/06/27
Structure-based discovery of a new series of nucleoside-derived ring-opening PRMT5 inhibitors 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 267, 页码: 19
作者:  Chen, Yuting;  Wang, Zekun;  Zhang, Junjie;  Shi, Qiongyu;  Yang, Hong;  Deng, Yue;  Wang, Xingcan;  Liu, Tongchao;  Geng, Meiyu;  Xiong, Bing;  Huang, Xun
收藏  |  浏览/下载：74/0  |  提交时间：2024/05/07
PRMT5  Nucleoside derivatives  Methyltransferases  Structure -activity relationship  
Hyodeoxycholic acid ameliorates nonalcoholic fatty liver disease by inhibiting RAN-mediated PPARa nucleus-cytoplasm shuttling 期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 18
作者:  Zhong, Jing;  He, Xiaofang;  Gao, Xinxin;  Liu, Qiaohong;  Zhao, Yu;  Hong, Ying;  Zhu, Weize;  Yan, Juan;  Li, Yifan;  Li, Yan;  Zheng, Ningning;  Bao, Yiyang;  Wang, Hao;  Ma, Junli;  Huang, Wenjin;  Liu, Zekun;  Lyu, Yuanzhi;  Ke, Xisong;  Jia, Wei;  Xie, Cen;  Hu, Yiyang;  Sheng, Lili;  Li, Houkai
收藏  |  浏览/下载：55/0  |  提交时间：2023/12/08
Structure-activity relationship study of a series of nucleoside derivatives bearing sulfonamide scaffold as potent and selective PRMT5 inhibitors 期刊论文
BIOORGANIC CHEMISTRY, 2023, 卷号: 130, 页码: 20
作者:  Chen, Yuting;  Shi, Qiongyu;  Yang, Hong;  Li, Jiayi;  Zhou, Kaixin;  Zhang, Junjie;  Wang, Zekun;  Shi, Huanyu;  Xiong, Bing;  Liu, Jia;  Huang, Xun;  Liu, Tongchao
收藏  |  浏览/下载：82/0  |  提交时间：2023/04/10
Epigenetic  PRMT5 inhibitor  Nucleoside derivatives  Structure-activity Relationship Prodrug  
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