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Heterocycle-fused phenylcyclohexylamines as novel multi-target antagonists of N-methyl-D-aspartate (NMDA) receptor and monoamine transporter for treating depression 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 291, 页码: 20
作者:  Zheng, Fuqiang;  Hu, Zhengtao;  Chen, Hai;  Cheng, Jiaxin;  Hou, Qiongqiong;  Zheng, Jiefang;  Gong, Xudong;  Ji, Jing;  Zayniddin, Nuriddinov;  Abduahadi, Safomuddin;  Mamateli, Obul;  Wang, Guan;  Li, Pengcheng;  Hu, Tianwen;  Tian, Guanghui;  Xu, Zhijian;  Zhu, Weiliang;  Aisa, Haji Akber;  Shen, Jingshan;  He, Yang
收藏  |  浏览/下载：12/0  |  提交时间：2025/06/23
Heterocycle-fused phenylcyclohexylamines  Multi-target antagonists  NMDAR  Monoamine transporter  Antidepressants  
Covalent DNA-Encoded Library Workflow Drives Discovery of SARS-CoV-2 Nonstructural Protein Inhibitors 期刊论文
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, 2024, 页码: 14
作者:  Wang, Xudong;  Xiong, Liwei;  Zhu, Ying;  Liu, Sixiu;  Zhao, Wenfeng;  Wu, Xinyuan;  Seydimemet, Mengnisa;  Li, Linjie;  Ding, Peiqi;  Lin, Xian;  Liu, Jiaxiang;  Wang, Xuan;  Duan, Zhiqiang;  Lu, Weiwei;  Suo, Yanrui;  Cui, Mengqing;  Yue, Jinfeng;  Jin, Rui;  Zheng, Mingyue;  Xu, Yechun;  Mei, Lianghe;  Hu, Hangchen;  Lu, Xiaojie
收藏  |  浏览/下载：33/0  |  提交时间：2024/12/25
Cannabidiol exhibits anxiolytic-like effects and antipsychotic-like effects in mice models 期刊论文
NEUROSCIENCE LETTERS, 2024, 卷号: 826, 页码: 8
作者:  Shu, Guangzhao;  He, Yang;  Suo, Jin;  Wu, Chunhui;  Gong, Xudong;  Xiang, Yangyang;  Yang, Wenjiao;  Cheng, Jiaxin;  Wang, Yu;  Chen, Weiming;  Shen, Jingshan
收藏  |  浏览/下载：41/0  |  提交时间：2024/06/27
Cannabidiol  Stress-induced hyperthermia  Phencyclidine-induced negative symptoms of  schizophrenia model  5-HT 1A receptor  
Chemical Space Profiling of SARS-CoV-2 PLpro Using DNA-Encoded Focused Libraries 期刊论文
ACS MEDICINAL CHEMISTRY LETTERS, 2024, 页码: 10
作者:  Wang, Xudong;  Zhu, Ying;  Zhao, Qingyi;  Lu, Weiwei;  Xu, Yechun;  Hu, Hangchen;  Lu, Xiaojie
收藏  |  浏览/下载：39/0  |  提交时间：2024/05/07
DNA-Encoded Focused Libraries (DEFLs)  SARS-CoV-2  Papain-like Protease  Library Design  ProteinInhibitors  

Stereoselective synthesis of 2-deoxy-2-disubstituted ribonolactones through a TiCl4-mediated Evans-Aldol reaction

 期刊论文
TETRAHEDRON LETTERS, 2022, 卷号: 95, 页码: 6
作者:  Liu, He;  Yang, Wenjiao;  Zheng, Shaojiu;  He, Yang;  Wang, Guan;  Qin, Hongjian;  Zhu, Fuqiang;  Jiang, Xiangrui;  Shen, Jingshan;  Gong, Xudong
收藏  |  浏览/下载：60/0  |  提交时间：2022/08/16
Asymmetric synthesis  Stereoselectivity  Ribonolactone  Evans-Aldol reaction  
Pharmacokinetics-Driven Optimization of 4(3H)-Pyrimidinones as Phosphodiesterase Type 5 Inhibitors Leading to TPN171, a Clinical Candidate for the Treatment of Pulmonary Arterial Hypertension 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2019, 卷号: 62, 期号: 10, 页码: 4979-4990
作者:  Wang, Zhen;  Jiang, Xiangrui;  Zhang, Xianglei;  Tian, Guanghui;  Yang, Rulei;  Wu, Jianzhong;  Zou, Xiaoli;  Liu, Zheng;  Yang, Xiaojun;  Wu, Chunhui;  Shi, Jing;  Li, Jianfeng;  Suo, Jin;  Wang, Yu;  Zhang, Rongxia;  Xu, Zhijian;  Gong, Xudong;  He, Yang;  Zhu, Weiliang;  Aisa, Haji Akber;  Jiang, Hualiang;  Xu, Yechun;  Shen, Jingshan
收藏  |  浏览/下载：73/0  |  提交时间：2020/07/01
Exploration of the 5-bromopyrimidin-4(3H)-ones as potent inhibitors of PDE5 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS, 2013, 卷号: 23, 期号: 17, 页码: 4944-4947
作者:  Gong, Xudong;  Wang, Guan;  Ren, Jing;  Liu, Zheng;  Wang, Zhen;  Chen, Tiantian;  Yang, Xiaojun;  Jiang, Xiangrui;  Shen, Jingshan;  Jiang, Hualiang;  Aisa, Haji Akber;  Xu, Yechun;  Li, Jianfeng
收藏  |  浏览/下载：57/0  |  提交时间：2019/01/08
PDE5 inhibitors  5-Bromopyrimidin-4(3H)-ones  
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