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Relief of loperamide-induced constipation by peptidic and small molecule RXFP4 agonists in mice 期刊论文
BIOCHEMICAL PHARMACOLOGY, 2025, 卷号: 237, 页码: 12
作者:  Yan, Shiyu;  Chen, Yan;  Wang, Jiang;  Wang, Qiuying;  Zhou, Qingtong;  Liu, Hong;  Wang, Ming-Wei;  Yang, Dehua
收藏  |  浏览/下载：9/0  |  提交时间：2025/06/23
RXFP4  INSL5  Agonist  Constipation  Colonic motility  
Enriched pathways in gut microbiome predict response to immune checkpoint inhibitor treatment across demographic regions and various cancer types 期刊论文
ISCIENCE, 2025, 卷号: 28, 期号: 4, 页码: 21
作者:  Cai, Xunhui;  Cho, Jennifer Y.;  Chen, Lijun;  Liu, Yufeng;  Ji, Fenghu;  Salgado, Katia;  Ge, Siyi;  Yang, Dehua;  Yu, Hui;  Shao, Jianbo;  Futreal, P. Andrew;  Sepesi, Boris;  Gibbons, Don;  Chen, Yaobing;  Wang, Guoping;  Cheng, Chao;  Wu, Meng;  Zhang, Jianjun;  Hsiao, Ansel;  Xia, Tian
收藏  |  浏览/下载：6/0  |  提交时间：2025/05/27
Molecular mechanisms of urate transport by the native human URAT1 and its inhibition by anti-gout drugs 期刊论文
CELL DISCOVERY, 2025, 卷号: 11, 期号: 1, 页码: 12
作者:  Wu, Canrong;  Zhang, Chao;  Jin, Sanshan;  Wang, James Jiqi;  Dai, Antao;  Xu, Jiuyin;  Zhang, Heng;  Yang, Xuemei;  He, Xinheng;  Yuan, Qingning;  Hu, Wen;  Xu, Youwei;  Wang, Mingwei;  Jiang, Yi;  Yang, Dehua;  Xu, H. Eric
收藏  |  浏览/下载：14/0  |  提交时间：2025/05/27
Computation-Enabled Structure-Based Discovery of Potent Binders for Small-Molecule Aptamers 期刊论文
JOURNAL OF CHEMICAL THEORY AND COMPUTATION, 2025, 卷号: 21, 期号: 6, 页码: 3216-3230
作者:  Zhou, Qingtong;  Zhang, Zheng;  Gao, Ling;  Li, Guanyi;  Zhang, Yue;  Yang, Weili;  Zhao, Yaxue;  Yang, Dehua;  Wang, Ming-Wei;  Luo, Zhaofeng;  Xia, Xiaole
收藏  |  浏览/下载：12/0  |  提交时间：2025/04/24
Weight Loss Blockbuster Development: A Role for Unimolecular Polypharmacology 期刊论文
ANNUAL REVIEW OF PHARMACOLOGY AND TOXICOLOGY, 2025, 卷号: 65, 页码: 191-213
作者:  Zhou, Qingtong;  Li, Guanyi;  Hang, Kaini;  Li, Jie;  Yang, Dehua;  Wang, Ming-Wei
收藏  |  浏览/下载：29/0  |  提交时间：2025/04/01
overweight  glucagon-like peptide-1 receptor  unimolecular  polypharmacology  tirzepatide  retatrutide  metabolic diseases  
Talaketides A-G, linear polyketides with prostate cancer cytotoxic activity from the mangrove sediment-derived fungus Talaromyces sp. SCSIO 41027 期刊论文
CHINESE JOURNAL OF NATURAL MEDICINES, 2024, 卷号: 22, 期号: 11, 页码: 1047-1056
作者:  Chen, Chunmei;  Wang, Xueni;  Fang, Wenxuan;  Liang, Jiaqi;  Cai, Jian;  Yang, Dehua;  Luo, Xiaowei;  Gao, Chenghai;  Yi, Xiangxi;  Liu, Yonghong;  Zhou, Xuefeng
收藏  |  浏览/下载：22/0  |  提交时间：2024/12/11
[KEY WORDS] Mangrove sediment-derived fungus  Talaromyces sp.  Linear polyketides  Cytotoxicity  Prostate cancer.  
Molecular basis of enhanced GLP-1 signaling mediated by GLP-1(9-36) in conjunction with LSN3318839 期刊论文
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 11, 页码: 5069-5073
作者:  Li, Jie;  Li, Guanyi;  Mai, Yiting;  Liu, Xiao;  Yang, Dehua;  Zhou, Qingtong;  Wang, Ming-Wei
收藏  |  浏览/下载：66/0  |  提交时间：2025/01/06
GLP-1(9-36)  Cryo-electron microscopy  Metabolite  Allosteric modulation  
Single-cell mapping of peripheral blood mononuclear cells reveals key transcriptomic changes favoring coronary artery lesion in IVIG-resistant Kawasaki disease 期刊论文
HELIYON, 2024, 卷号: 10, 期号: 18, 页码: 15
作者:  Zheng, Yuanzheng;  Zhou, Yan;  Zhu, Di;  Fu, Xing;  Xie, Cao;  Sun, Shuna;  Qin, Guoyou;  Feng, Mei;  Liu, Chenglong;  Zhou, Qingtong;  Liu, Fang;  Chu, Chen;  Wang, Feng;  Yang, Dehua;  Wang, Ming-Wei;  Gui, Yonghao
收藏  |  浏览/下载：53/0  |  提交时间：2024/10/21
Kawasaki disease  IVIG-Resistant  Single cell RNA-Sequencing  Coronary artery lesion  
Single-cell sequencing reveals the heterogeneity of pancreatic neuroendocrine tumors under genomic instability and histological grading 期刊论文
ISCIENCE, 2024, 卷号: 27, 期号: 9, 页码: 18
作者:  Ye, Zeng;  Zhou, Yan;  Hu, Yuheng;  Li, Qiang;  Xu, Zijin;  Lou, Xin;  Zhang, Wuhu;  Zhu, Di;  Xie, Cao;  Zhou, Qingtong;  Gao, Jing;  Zhou, Hu;  Yang, Dehua;  Qin, Yi;  Xu, Xiaowu;  Chen, Jie;  Ji, Shunrong;  Wang, Ming-Wei;  Yu, Xianjun
收藏  |  浏览/下载：41/0  |  提交时间：2024/11/05
tumor cells  CNV neutral tumor cells  neuroendocrine cells  profile  
Absence of PNET formation and normal longevity in a mouse model of Mahvash disease 期刊论文
HELIYON, 2024, 卷号: 10, 期号: 15, 页码: 13
作者:  Xu, Yingna;  Liu, Qiaofeng;  Chen, Chuan-Wei;  Wang, Qiuying;  Du, Tianyuan;  Yu, Run;  Zhou, Qingtong;  Yang, Dehua;  Wang, Ming-Wei
收藏  |  浏览/下载：37/0  |  提交时间：2024/09/26
Glucagon  Glucagon receptor  Amino acid  Metabolism  Mahvash disease  
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