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Uncommon Diterpenoids with Diverse Frameworks from the South China Sea Sponge Spongia officinalis and Their Anti-inflammatory Activities 期刊论文
JOURNAL OF ORGANIC CHEMISTRY, 2025, 卷号: 90, 期号: 5, 页码: 1950-1956
Authors:  Li, Song-Wei;  Liu, Jiao;  Liu, Zi-Yi;  Fu, Yan;  Yao, Li-Gong;  Gu, Yu-Cheng;  Zhang, Hai-Yan;  Li, Xu-Wen;  Guo, Yue-Wei
Favorite  |  View/Download：4/0  |  Submit date：2025/04/01
FMP-6-S4 impeded Aβ42 induced SH-SY5Y cell injury by targeting cyclophilin D 期刊论文
JOURNAL OF FUNCTIONAL FOODS, 2024, 卷号: 119, 页码: 9
Authors:  Gao, Pengcheng;  Li, Saijuan;  Wang, Yuyong;  Wu, Fangge;  Jin, Can;  Zhao, Danfeng;  Zhang, Haiyan;  Liao, Wenfeng;  Ding, Kan
Favorite  |  View/Download：41/0  |  Submit date：2024/11/05
Alzheimer's disease  Fructus Mori  Amyloid beta  Cyclophilin D  Mitochondrial permeability transition pore  Glycopeptide  
ABBV-744 alleviates LPS-induced neuroinflammation via regulation of BATF2-IRF4-STAT1/3/5 axis 期刊论文
ACTA PHARMACOLOGICA SINICA, 2024, 页码: 15
Authors:  Wang, Le-le;  Wang, Huan;  Lin, Si-jin;  Xu, Xing-yu;  Hu, Wen-juan;  Liu, Jia;  Zhang, Hai-yan
Favorite  |  View/Download：58/0  |  Submit date：2024/07/12
microglial inflammation  BD2  ABBV-744  BATF2  IRF4  JAK/STAT  
Anti-inflammatory Steroids from the South China Sea Sponge Spongia officinalis 期刊论文
CHEMISTRY & BIODIVERSITY, 2024, 页码: 5
Authors:  Liu, Jiao;  Liu, Zi-Yi;  Fu, Yan;  Gu, Yu-Cheng;  Li, Song-Wei;  Zhang, Hai-Yan;  Guo, Yue-Wei
Favorite  |  View/Download：76/0  |  Submit date：2024/05/31
Sponge  Spongia officinalis  Chemical investigation  Absolute configuration  Anti-inflammatory activity  
Design, Synthesis, and Biological Evaluation of Novel Tetrahydroacridin Hybrids with Sulfur-Inserted Linkers as Potential Multitarget Agents for Alzheimer's Disease 期刊论文
MOLECULES, 2024, 卷号: 29, 期号: 8, 页码: 17
Authors:  Wu, Xiuyuan;  Ze, Xiaotong;  Qin, Shuai;  Zhang, Beiyu;  Li, Xinnan;  Gong, Qi;  Zhang, Haiyan;  Zhu, Zheying;  Xu, Jinyi
Favorite  |  View/Download：80/0  |  Submit date：2024/06/27
Alzheimer's disease  tacrine  cystamine  MTDLs  inhibitors  molecular modeling  
A novel BODIPY-based theranostic agent for in vivo fluorescence imaging of cerebral Aβ and ameliorating Aβ-associated disorders in Alzheimer's disease transgenic mice 期刊论文
RSC MEDICINAL CHEMISTRY, 2024, 页码: 9
Authors:  Zhang, Jingjing;  Ren, Wenming;  Liu, Xiaohui;  Chen, Jingjing;  Zeng, Yuteng;  Xiang, Huaijiang;  Hu, Youhong;  Zhang, Haiyan
Favorite  |  View/Download：56/0  |  Submit date：2024/05/07
JE-133 Suppresses LPS-Induced Neuroinflammation Associated with the Regulation of JAK/STAT and Nrf2 Signaling Pathways 期刊论文
ACS CHEMICAL NEUROSCIENCE, 2024, 卷号: 15, 期号: 2, 页码: 258-267
Authors:  Tao, Lingxue;  Yu, Weichen;  Liu, Ziyi;  Zhao, Danfeng;  Lin, Sijin;  Szaloki, Dora;  Kicsak, Mate;  Kurtan, Tibor;  Zhang, Haiyan
Favorite  |  View/Download：60/0  |  Submit date：2024/02/27
neuroinflammation  microglia  LPS  JAK/STAT  Nrf2  
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects 期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
Authors:  Yang, Xin-Mei;  Yang, Yang;  Yao, Bu-Fan;  Ye, Pan-Pan;  Xu, Yan;  Peng, Shao-Ping;  Yang, Yu-Mei;  Shu, Pan;  Li, Pei-Jin;  Li, Shan;  Hu, Hong-Lin;  Li, Qian;  Song, Lin-Lin;  Chen, Ke-Guang;  Zhou, Hai-Yan;  Zhang, Ye-Hui;  Zhao, Fu-Rong;  Tang, Bo-Hao;  Zhang, Wei;  Zhang, Xin-Fang;  Fu, Shu-Meng;  Hao, Guo-Xiang;  Zheng, Yi;  Shen, Jing-Shan;  Xu, Ye-Chun;  Jiang, Xiang-Rui;  Zhang, Lei-Ke;  Tang, Ren-Hong;  Zhao, Wei
Favorite  |  View/Download：67/0  |  Submit date：2023/12/11
COVID-19  Simnotrelvir  Safety  Pharmacokinetics  Healthy subjects  
Anxiolytic effect of antidiabetic metformin is mediated by AMPK activation in mPFC inhibitory neurons 期刊论文
MOLECULAR PSYCHIATRY, 2023, 页码: 11
Authors:  Zhang, Yong-mei;  Zong, Hai-chao;  Qi, Ying-bei;  Chang, Liu-liu;  Gao, Ya-nan;  Zhou, Ting;  Yin, Tao;  Liu, Meng;  Pan, Kai-jun;  Chen, Wen-gang;  Guo, Hao-ran;  Guo, Fei;  Peng, Yan-min;  Wang, Min;  Feng, Lin-yin;  Zang, Yi;  Li, Yang;  Li, Jia
Favorite  |  View/Download：63/0  |  Submit date：2023/12/08
Densely Functionalized Macrocyclic Sesquiterpene Pyridine Alkaloids from Maytenus austroyunnanensis 期刊论文
JOURNAL OF NATURAL PRODUCTS, 2023, 页码: 11
Authors:  Ji, Kai-Long;  Fan, Yao-Yue;  Gong, Qi;  Liu, Qun-Fang;  Cui, Ming-Jun;  Fu, Kai-Cong;  Zhang, Hai-Yan;  Yue, Jian-Min
Favorite  |  View/Download：61/0  |  Submit date：2023/12/08
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