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Assembly and architecture of endogenous NMDA receptors in adult cerebral cortex and hippocampus 期刊论文
CELL, 2025, 卷号: 188, 期号: 5, 页码: 24
作者:  Zhang, Ming;  Feng, Juan;  Xie, Chun;  Song, Nan;  Jin, Chaozhi;  Wang, Jian;  Zhao, Qun;  Zhang, Lihua;  Wang, Boshuang;  Sun, Yidi;  Guo, Fei;  Li, Yang;  Zhu, Shujia
收藏  |  浏览/下载：47/0  |  提交时间：2025/04/24
Mass balance, metabolism, and pharmacokinetics of [14C]amdizalisib, a clinical-stage novel oral selective PI3Kδ inhibitor for the treatment of non-hodgkin's lymphoma, in healthy Chinese volunteers 期刊论文
FRONTIERS IN PHARMACOLOGY, 2024, 卷号: 15, 页码: 13
作者:  Zhao, Chun-Yang;  Zhang, Li-Jun;  Sun, Chan;  Yu, Cheng-Yin;  Wang, Jian;  Sai, Yang;  Su, Wei-Guo;  Chen, Qian;  Wang, Wei;  Jia, Jing-Ying;  Liu, Gang-Yi;  Liu, Yan-Mei
收藏  |  浏览/下载：64/0  |  提交时间：2025/01/06
amdizalisib  PI3K delta kinase  metabolism  mass balance  metabolite identification  pharmacokinetics  safety  
Atranorin inhibits Zika virus infection in human glioblastoma cell line SNB-19 via targeting Zika virus envelope protein 期刊论文
PHYTOMEDICINE, 2024, 卷号: 125, 页码: 11
作者:  Huang, Guan-gen;  Wang, Hao-yu;  Wang, Xiao-han;  Yang, Tao;  Zhang, Xiao-meng;  Feng, Chun-lan;  Zhao, Wei-min;  Tang, Wei
收藏  |  浏览/下载：53/0  |  提交时间：2024/05/07
Zika virus  SNB-19 cells  Atranorin  Envelope protein  Entry stage  Antiviral drugs  
A first-in-human phase 1 study of simnotrelvir, a 3CL-like protease inhibitor for treatment of COVID-19, in healthy adult subjects 期刊论文
EUROPEAN JOURNAL OF PHARMACEUTICAL SCIENCES, 2023, 卷号: 191, 页码: 9
作者:  Yang, Xin-Mei;  Yang, Yang;  Yao, Bu-Fan;  Ye, Pan-Pan;  Xu, Yan;  Peng, Shao-Ping;  Yang, Yu-Mei;  Shu, Pan;  Li, Pei-Jin;  Li, Shan;  Hu, Hong-Lin;  Li, Qian;  Song, Lin-Lin;  Chen, Ke-Guang;  Zhou, Hai-Yan;  Zhang, Ye-Hui;  Zhao, Fu-Rong;  Tang, Bo-Hao;  Zhang, Wei;  Zhang, Xin-Fang;  Fu, Shu-Meng;  Hao, Guo-Xiang;  Zheng, Yi;  Shen, Jing-Shan;  Xu, Ye-Chun;  Jiang, Xiang-Rui;  Zhang, Lei-Ke;  Tang, Ren-Hong;  Zhao, Wei
收藏  |  浏览/下载：70/0  |  提交时间：2023/12/11
COVID-19  Simnotrelvir  Safety  Pharmacokinetics  Healthy subjects  
Structure-based development and preclinical evaluation of the SARS-CoV-2 3C-like protease inhibitor simnotrelvir 期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 15
作者:  Jiang, Xiangrui;  Su, Haixia;  Shang, Weijuan;  Zhou, Feng;  Zhang, Yan;  Zhao, Wenfeng;  Zhang, Qiumeng;  Xie, Hang;  Jiang, Lei;  Nie, Tianqing;  Yang, Feipu;  Xiong, Muya;  Huang, Xiaoxing;  Li, Minjun;  Chen, Ping;  Peng, Shaoping;  Xiao, Gengfu;  Jiang, Hualiang;  Tang, Renhong;  Zhang, Leike;  Shen, Jingshan;  Xu, Yechun
收藏  |  浏览/下载：50/0  |  提交时间：2024/03/25
Building Block Extractor: An MS/MS Data Mining Tool for Targeted Discovery of Natural Products with Specified Features 期刊论文
ANALYTICAL CHEMISTRY, 2023, 页码: 8
作者:  Zhu, Dafu;  Yuan, Jie;  Yue, Quanqi;  Zhao, Yinggong;  Yu, Shan;  Zhamilya, Abilova;  Jenis, Janar;  Tang, Chunping;  Wang, Bo;  Liu, Jia;  Ye, Yang
收藏  |  浏览/下载：102/0  |  提交时间：2023/10/17
Prime editing-based gene correction alleviates the hyperexcitable phenotype and seizures of a genetic epilepsy mouse model 期刊论文
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 4
作者:  Cao, Bi-rong;  Huang, Yi-ming;  Tian, Fu-yun;  Li, Jin-hui;  Xu, Chun-long;  Wei, Yu;  Liu, Ji-kai;  Guo, Qian-bei;  Xu, Hai-yan;  Zhan, Li;  Lv, Rui-min;  Sun, Yi-di;  Hu, Xin-de;  Gao, Zhao-bing;  Zhou, Chang-yang
收藏  |  浏览/下载：60/0  |  提交时间：2023/10/17
Naphthylisoquinoline alkaloids, a new structural template inhibitor of Nav1.7 sodium channel 期刊论文
ACTA PHARMACOLOGICA SINICA, 2023, 页码: 9
作者:  Wang, Qiao-qiao;  Wang, Long;  Zhang, Wen-bo;  Tang, Chun-ping;  Chen, Xue-qin;  Zheng, Yue-ming;  Yao, Sheng;  Gao, Zhao-bing;  Ye, Yang
收藏  |  浏览/下载：60/0  |  提交时间：2023/10/17
Nav1.7 channel  naphthylisoquinolines  Ancistrocladus tectorius  dorsal root ganglion neurons  formalin-induced mouse inflammatory pain model  analgesics  
Ligand recognition mechanism of the human relaxin family peptide receptor 4 (RXFP4) 期刊论文
NATURE COMMUNICATIONS, 2023, 卷号: 14, 期号: 1, 页码: 492
作者:  Chen, Yan;  Zhou, Qingtong;  Wang, Jiang;  Xu, Youwei;  Wang, Yun;  Yan, Jiahui;  Wang, Yibing;  Zhu, Qi;  Zhao, Fenghui;  Li, Chenghao;  Chen, Chuan-Wei;  Cai, Xiaoqing;  Bathgate, Ross A. . D.;  Shen, Chun;  Xu, H. Eric;  Yang, Dehua;  Liu, Hong;  Wang, Ming-Wei
收藏  |  浏览/下载：57/0  |  提交时间：2024/03/27
High-throughput screening of SARS-CoV-2 main and papain-like protease inhibitors 期刊论文
PROTEIN & CELL, 2023, 卷号: 14, 期号: 1, 页码: 17-27
作者:  Zang, Yi;  Su, Mingbo;  Wang, Qingxing;  Cheng, Xi;  Zhang, Wenru;  Zhao, Yao;  Chen, Tong;  Jiang, Yingyan;  Shen, Qiang;  Du, Juan;  Tan, Qiuxiang;  Wang, Peipei;  Gao, Lixin;  Jin, Zhenming;  Zhang, Mengmeng;  Li, Cong;  Zhu, Ya;  Feng, Bo;  Tang, Bixi;  Xie, Han;  Wang, Ming-Wei;  Zheng, Mingyue;  Pan, Xiaoyan;  Yang, Haitao;  Xu, Yechun;  Wu, Beili;  Zhang, Leike;  Rao, Zihe;  Yang, Xiuna;  Jiang, Hualiang;  Xiao, Gengfu;  Zhao, Qiang;  Li, Jia
收藏  |  浏览/下载：64/0  |  提交时间：2024/03/27
high-throughput screening  SARS  CoV-2  main  papain-like  proteases  
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