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Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10
Authors:  Zeng, Yanping;  Xiao, Jian;  Shi, Li;  Li, Yangsha;  Xu, Yuanxin;  Zhou, Jiayun;  Dong, Xiao;  Hou, Haiyang;  Zhong, Chao;  Cheng, Gang;  Chen, Yi;  Zhang, Naixia;  Fang, Yanfen;  Hu, Youhong
Favorite  |  View/Download：15/0  |  Submit date：2025/04/01
LC3B  CDK9  Degradation  Protein complex  
Auto-RapTAC: A Versatile and Sustainable Platform for the Automated Rapid Synthesis and Evaluation of PROTAC 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2025, 页码: 15
Authors:  Chen, Jiexuan;  Wu, Mingfei;  Mo, Jun;  Hong, Ju;  Wang, Wei;  Jin, Yuheng;  Mao, Xinfei;  Liao, Xueyan;  Li, Kailin;  Yu, Xiaoli;  Chen, Sikang;  Zeng, Shenxin;  Huang, Wenhai;  Xu, Hongxia;  Wu, Jian;  Cao, Ji;  Zhou, Yubo;  Ying, Meidan;  Zhu, Chengliang;  He, Qiaojun;  Zhang, Bo;  Lin, Nengming;  Dong, Xiaowu;  Che, Jinxin
Favorite  |  View/Download：14/0  |  Submit date：2025/04/01
π-HuB: the proteomic navigator of the human body 期刊论文
NATURE, 2024, 卷号: 636, 期号: 8042, 页码: 322-331
Authors:  He, Fuchu;  Aebersold, Ruedi;  Baker, Mark S.;  Bian, Xiuwu;  Bo, Xiaochen;  Chan, Daniel W.;  Chang, Cheng;  Chen, Luonan;  Chen, Xiangmei;  Chen, Yu-Ju;  Cheng, Heping;  Collins, Ben C.;  Corrales, Fernando;  Cox, Juergen;  Weinan, E.;  Van Eyk, Jennifer E.;  Fan, Jia;  Faridi, Pouya;  Figeys, Daniel;  Gao, George Fu;  Gao, Wen;  Gao, Zu-Hua;  Goda, Keisuke;  Goh, Wilson Wen Bin;  Gu, Dongfeng;  Guo, Changjiang;  Guo, Tiannan;  He, Yuezhong;  Heck, Albert J. R.;  Hermjakob, Henning;  Hunter, Tony;  Iyer, Narayanan Gopalakrishna;  Jiang, Ying;  Jimenez, Connie R.;  Joshi, Lokesh;  Kelleher, Neil L.;  Li, Ming;  Li, Yang;  Lin, Qingsong;  Liu, Cui Hua;  Liu, Fan;  Liu, Guang-Hui;  Liu, Yansheng;  Liu, Zhihua;  Low, Teck Yew;  Lu, Ben;  Mann, Matthias;  Meng, Anming;  Moritz, Robert L.;  Nice, Edouard;  Ning, Guang;  Omenn, Gilbert S.;  Overall, Christopher M.;  Palmisano, Giuseppe;  Peng, Yaojin;  Pineau, Charles;  Poon, Terence Chuen Wai;  Purcell, Anthony W.;  Qiao, Jie;  Reddel, Roger R.;  Robinson, Phillip J.;  Roncada, Paola;  Sander, Chris;  Sha, Jiahao;  Song, Erwei;  Srivastava, Sanjeeva;  Sun, Aihua;  Sze, Siu Kwan;  Tang, Chao;  Tang, Liujun;  Tian, Ruijun;  Vizcaino, Juan Antonio;  Wang, Chanjuan;  Wang, Chen;  Wang, Xiaowen;  Wang, Xinxing;  Wang, Yan;  Weiss, Tobias;  Wilhelm, Mathias;  Winkler, Robert;  Wollscheid, Bernd;  Wong, Limsoon;  Xie, Linhai;  Xie, Wei;  Xu, Tao;  Xu, Tianhao;  Yan, Liying;  Yang, Jing;  Yang, Xiao;  Yates, John;  Yun, Tao;  Zhai, Qiwei;  Zhang, Bing;  Zhang, Hui;  Zhang, Lihua;  Zhang, Lingqiang;  Zhang, Pingwen;  Zhang, Yukui;  Zheng, Yu Zi;  Zhong, Qing;  Zhu, Yunping;  Tan, Chris Soon Heng;  Gao, Mingxia;  Gao, Qiang;  Gao, Yushun;  Guo, Xuejiang;  He, Jie;  He, Jun;  He, Qing-Yu;  Hou, Jinlin;  Huang, Canhua;  Jia, Chenxi;  Kuster, Bernhard;  Li, Chaoying;  Li, Dong;  Li, Yanchang;  Liu, Siqi;  Liu, Xiaonan;  Liu, Ya;  Liu, Zhongyang;  Lu, Haojie;  Nie, Yongzhan;  Okada, Mariko;  Qian, Guojun;  Qin, Hongqiang;  Rao, Yu;  Rao, Zihe;  Ren, Xianwen;  Ren, Yan;  Shen, Feng;  Shen, Lin;  Su, Shicheng;  Tan, Minjia;  Tang, Ben Zhong;  Tao, Sheng-Ce;  Wang, Jian;  Wang, Tong;  Wei, Liming;  Wong, Catherine C. L.;  Xie, Xiaoliang Sunney;  Xu, Li;  Xu, Ping;  Yang, Huanming;  Yang, Jianjun;  Ye, Mingliang;  Ying, Wantao;  Yu, Xiaobo;  Yuan, Yaxiang;  Zeng, Qingcun;  Zhan, Qimin;  Zhang, Xiaofei;  Zhang, Xu;  Zhang, Ying;  Zhong, Nan-Shan;  Zhou, Feng;  Zhu, Yi;  Zhang, Zemin
Favorite  |  View/Download：7/0  |  Submit date：2025/04/01
A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands 期刊论文
NATURE METHODS, 2024, 页码: 17
Authors:  Li, Kejia;  Chen, Shijie;  Wang, Keyun;  Wang, Yan;  Xue, Lianji;  Ye, Yuying;  Fang, Zheng;  Lyu, Jiawen;  Zhu, Haiyang;  Li, Yanan;  Yu, Ting;  Yang, Feng;  Zhang, Xiaolei;  Guo, Siqi;  Ruan, Chengfei;  Zhou, Jiahua;  Wang, Qi;  Dong, Mingming;  Luo, Cheng;  Ye, Mingliang
Favorite  |  View/Download：156/0  |  Submit date：2025/01/14
Optimization and Biological Evaluation of Novel 1H-Pyrrolo[2,3-c]pyridin Derivatives as Potent and Reversible Lysine Specific Demethylase 1 Inhibitors for the Treatment of Acute Myelogenous Leukemia 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 24, 页码: 22080-22103
Authors:  Jiang, Hong;  Li, Cong;  Li, Na;  Sheng, Li;  Wang, Jingkai;  Kan, Wei-Juan;  Chen, Yuelei;  Zhao, Dongmei;  Guo, Dong;  Zhou, Yu-Bo;  Xiong, Bing;  Li, Jia;  Liu, Tongchao
Favorite  |  View/Download：28/0  |  Submit date：2025/01/14
Discovery of N-Benzylpiperidinol derivatives as USP7 inhibitors against Hematology 期刊论文
BIOORGANIC CHEMISTRY, 2024, 卷号: 153, 页码: 13
Authors:  Pan, Youlu;  Chen, Haifeng;  Fu, Jingfeng;  Zhang, Jingyu;  Wang, Peipei;  Chen, Runmei;  Geng, Shuangshuang;  Che, Jinxin;  Dong, Xiaowu;  Zhou, Yubo;  Huang, Wenhai
Favorite  |  View/Download：64/0  |  Submit date：2024/10/21
Discovery of a potent PROTAC degrader for RNA demethylase FTO as antileukemic therapy 期刊论文
ACTA PHARMACEUTICA SINICA B, 2024, 卷号: 14, 期号: 12, 页码: 5382-5392
Authors:  Liu, Lu;  Qiu, Yuanlai;  Suo, Yuying;  Tong, Siyao;  Wang, Yiqing;  Zhang, Xi;  Chen, Liang;  Huang, Yue;  Zhou, Huchen;  Zhou, Hu;  Dong, Ze;  Yang, Cai-Guang
Favorite  |  View/Download：12/0  |  Submit date：2025/04/01
N 6-Methyladenosine  FTO  PROTAC  RNA epigenetics  Antileukemia  
Discovery of a Highly Potent and Selective BRD9 PROTAC Degrader Based on E3 Binder Investigation for the Treatment of Hematological Tumors 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 页码: 28
Authors:  Duan, Haiting;  Zhang, Jingyu;  Gui, Renzhao;  Lu, Yang;  Pang, Ao;  Chen, Beijing;  Shen, Liteng;  Yu, Hengyuan;  Li, Jia;  Xu, Tengfei;  Wang, Yuwei;  Yao, Xiaojun;  Zhang, Bo;  Lin, Nengming;  Dong, Xiaowu;  Zhou, Yubo;  Che, Jinxin
Favorite  |  View/Download：59/0  |  Submit date：2024/08/20
Farnesyltransferase inhibitor lonafarnib suppresses respiratory syncytial virus infection by blocking conformational change of fusion glycoprotein 期刊论文
SIGNAL TRANSDUCTION AND TARGETED THERAPY, 2024, 卷号: 9, 期号: 1, 页码: 14
Authors:  Yang, Qi;  Xue, Bao;  Liu, Fengjiang;  Lu, Yongzhi;  Tang, Jielin;  Yan, Mengrong;  Wu, Qiong;  Chen, Ruyi;  Zhou, Anqi;  Liu, Lijie;  Liu, Junjun;  Qu, Changbin;  Wu, Qingxin;  Fu, Muqing;  Zhong, Jiayi;  Dong, Jianwei;  Chen, Sijie;  Wang, Fan;  Zhou, Yuan;  Zheng, Jie;  Peng, Wei;  Shang, Jinsai;  Chen, Xinwen
Favorite  |  View/Download：44/0  |  Submit date：2024/07/12
Discovery of potent small molecule ubiquitin-specific protease 10 inhibitors with anti-hepatocellular carcinoma activity through regulating YAP expression 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 272, 页码: 21
Authors:  Lu, Yang;  Gao, Jian;  Wang, Peipei;  Chen, Haifeng;  He, Xinjun;  Luo, Mengxin;  Guo, Yu;  Li, Linjie;  Zhuang, Weihao;  Zhang, Bo;  Lin, Nengming;  Li, Jia;  Zhou, Yubo;  Dong, Xiaowu;  Che, Jinxin
Favorite  |  View/Download：66/0  |  Submit date：2024/07/12
Hepatocellular carcinoma  Ubiquitin-specific protease 10  Deubiquitination  Selectivity  
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