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Discovery of 2,4-quinazolinedione derivatives as LC3B recruiters in the facilitation of protein complex degradations 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2025, 卷号: 287, 页码: 10
作者:  Zeng, Yanping;  Xiao, Jian;  Shi, Li;  Li, Yangsha;  Xu, Yuanxin;  Zhou, Jiayun;  Dong, Xiao;  Hou, Haiyang;  Zhong, Chao;  Cheng, Gang;  Chen, Yi;  Zhang, Naixia;  Fang, Yanfen;  Hu, Youhong
收藏  |  浏览/下载：23/0  |  提交时间：2025/04/01
LC3B  CDK9  Degradation  Protein complex  
An antidepressant mechanism underlying the allosteric inhibition of GluN2D-incorporated NMDA receptors at GABAergic interneurons 期刊论文
SCIENCE ADVANCES, 2025, 卷号: 11, 期号: 10, 页码: 18
作者:  Zhang, Jilin;  Duan, Jinjin;  Li, Wei;  Wang, Xian;  Ren, Shimin;  Ye, Luyu;  Liu, Fang;  Tian, Xiaoting;  Xie, Yang;  Huang, Yiming;  Sun, Yidi;  Song, Nan;  Li, Tianyu;  Cai, Xiang;  Liu, Zhiqiang;  Zhou, Hu;  Huang, Chenggang;  Li, Yang;  Zhu, Shujia;  Guo, Fei
收藏  |  浏览/下载：9/0  |  提交时间：2025/04/24
Rubiadin Mediates the Upregulation of Hepatic Hepcidin and Alleviates Iron Overload via BMP6/SMAD1/5/9-Signaling Pathway 期刊论文
INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2025, 卷号: 26, 期号: 3, 页码: 14
作者:  Xie, Xueting;  Chang, Linyue;  Zhu, Xinyue;  Gong, Fengbei;  Che, Linlin;  Zhang, Rujun;  Wang, Lixin;  Gong, Chenyuan;  Fang, Cheng;  Yao, Chao;  Hu, Dan;  Zhao, Weimin;  Zhou, Yufu;  Zhu, Shiguo
收藏  |  浏览/下载：19/0  |  提交时间：2025/04/01
rubiadin  hepcidin  iron metabolism  iron overload  BMP6/SMAD1/5/9-signaling pathway  
Identifying a non-conserved site for achieving allosteric covalent inhibition of CECR2 期刊论文
ACTA PHARMACOLOGICA SINICA, 2025, 页码: 16
作者:  Tang, Cai-ling;  Li, Yuan-qing;  Du, Xi-kun;  Fang, Xiao-xia;  Guang, Yi-man;  Li, Pei-zhuo;  Chen, Shuang;  Xue, Sheng-yu;  Yu, Jia-min;  Liu, Xiao-yi;  Luo, Yi-pan;  Zhou, Lan-xin;  Luo, Cheng;  Xiong, Huan;  Liang, Zhong-jie;  Ding, Hong
收藏  |  浏览/下载：20/0  |  提交时间：2025/04/01
dynamics simulation  CECR2  covalent inhibitor  allosteric effect  
Design, synthesis and pharmacological evaluation of 1,2,3,4-tetrahydrobenzofuro[2,3-c] pyridine derivatives as p21-activated kinase 4 inhibitors for treatment of pancreatic cancer 期刊论文
ACTA PHARMACEUTICA SINICA B, 2025, 卷号: 15, 期号: 1, 页码: 438-466
作者:  Li, Yang;  Fang, Yan;  Chen, Xiaoyu;  Tong, Linjiang;  Feng, Fang;  Zhou, Qianqian;  Chen, Shulun;  Ding, Jian;  Xie, Hua;  Zhang, Ao
收藏  |  浏览/下载：82/0  |  提交时间：2025/04/01
P21-activated kinase 4  Tetrahydrobenzofuro[2  3-c]pyridine  Structure-activity relationship  Allosteric inhibitor  Pharmacokinetics properties  Kinase selectivity  Pancreatic cancer  Immune infiltration  
Synthesis and evaluation of hybrid molecules as RIPK1 and HDACs dual inhibitors 期刊论文
JOURNAL OF MOLECULAR STRUCTURE, 2024, 卷号: 1318, 页码: 13
作者:  Tang, Mingze;  Zhou, Xuan;  Shen, Qianqian;  Fang, Chen;  Peng, Xia;  Ji, Yinchun;  Zhu, Guijun;  Geng, Meiyu;  Chen, Yi;  Duan, Wenhu;  Ai, Jing;  Zhang, Hefeng
收藏  |  浏览/下载：287/0  |  提交时间：2024/08/22
Receptor -interacting protein kinase 1  Histone deacetylases  Inhibitor  Molecular dynamics (MD) simulation  ADMET analysis  
A peptide-centric local stability assay enables proteome-scale identification of the protein targets and binding regions of diverse ligands 期刊论文
NATURE METHODS, 2024, 页码: 17
作者:  Li, Kejia;  Chen, Shijie;  Wang, Keyun;  Wang, Yan;  Xue, Lianji;  Ye, Yuying;  Fang, Zheng;  Lyu, Jiawen;  Zhu, Haiyang;  Li, Yanan;  Yu, Ting;  Yang, Feng;  Zhang, Xiaolei;  Guo, Siqi;  Ruan, Chengfei;  Zhou, Jiahua;  Wang, Qi;  Dong, Mingming;  Luo, Cheng;  Ye, Mingliang
收藏  |  浏览/下载：157/0  |  提交时间：2025/01/14
Slow Metabolism-Driven Amplification of Hepatic PPARγ Agonism Mediates Benzbromarone-Induced Obesity-Specific Liver Injury 期刊论文
ADVANCED SCIENCE, 2024, 页码: 14
作者:  Li, Guanting;  Hu, Yourong;  Zhao, Han;  Peng, Ziyu;  Shang, Xin;  Zhang, Jia;  Xie, Kunxin;  Li, Meiwei;  Zhou, Xiaohang;  Zhou, Qinyao;  Li, Kai;  Zhou, Fang;  Wang, Heyao;  Xu, Zhijian;  Liu, Jiali;  Sun, Peng
收藏  |  浏览/下载：63/0  |  提交时间：2025/01/06
benzbromarone  drug-induced liver injury  drug metabolism  obesity  PPAR gamma  
Design and synthesis of pyridazin-4-one derivatives as necroptosis inhibitors 期刊论文
ARCHIV DER PHARMAZIE, 2024, 页码: 16
作者:  An, Yuxiang;  Peng, Xia;  Wang, Tianchen;  Liu, Kaiyuan;  Feng, Dazhi;  Fang, Chen;  Zhou, Xuan;  Geng, Meiyu;  Duan, Wenhu;  Ai, Jing;  Zhang, Hefeng
收藏  |  浏览/下载：24/0  |  提交时间：2024/12/25
inhibitor  pharmacokinetic study  pyridazin-4-one  receptor-interacting protein kinase 1  selectivity  
Design, Synthesis, and Biological Evaluation of Novel Diaminopyrimidine Macrocycles as Fourth Generation Reversible EGFR Inhibitors That Overcome Clinical Resistance to Osimertinib Mediated by C797S Mutation 期刊论文
JOURNAL OF MEDICINAL CHEMISTRY, 2024, 卷号: 67, 期号: 22, 页码: 20531-20558
作者:  Hu, Shiliang;  Tong, Linjiang;  Qin, Qiao;  Wen, Jiaxin;  Li, Yan;  Feng, Fang;  Wu, Kunzhong;  Zhou, Yang;  Shang, Jinsai;  Wang, Junjian;  Liu, Jinbao;  Xie, Hua;  Lu, Xiaoyun
收藏  |  浏览/下载：32/0  |  提交时间：2024/12/11
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