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Discovery of histone deacetylase 3 (HDAC3)-specific PROTACs 期刊论文
CHEMICAL COMMUNICATIONS, 2020, 卷号: 56, 期号: 68, 页码: 9866-9869
Authors:  Xiao, Yufeng;  Wang, Jia;  Zhao, Lisa Y.;  Chen, Xinyi;  Zheng, Guangrong;  Zhang X(张翾);  Liao, Daiqing
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Discovery of IAP-recruiting BCL-X-L PROTACs as potent degraders across multiple cancer cell lines 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 199, 页码: 112397
Authors:  Zhang X(张翾);  He, Yonghan;  Zhang, Peiyi;  Budamagunta, Vivekananda;  Lv, Dongwen;  Thummuri, Dinesh;  Yang, Yang;  Pei, Jing;  Yuan, Yaxia;  Zhou, Daohong;  Zheng, Guangrong
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Bcl-x-l  Protac  Sniper  Iaps  Degradation  
DT2216-a Bcl-xL-specific degrader is highly active against Bcl-xL-dependent T cell lymphomas 期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2020, 卷号: 13, 期号: 1, 页码: 95
Authors:  He, Yonghan;  Koch, Raphael;  Budamagunta, Vivekananda;  Zhang, Peiyi;  Zhang X(张翾);  Khan, Sajid;  Thummuri, Dinesh;  Ortiz, Yuma T.;  Zhang, Xin;  Lv, Dongwen;  Wiegand, Janet S.;  Li, Wen;  Palmer, Adam C.;  Zheng, Guangrong;  Weinstock, David M.;  Zhou, Daohong
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t Cell Lymphoma  Bcl-xl  Vhl  Protac  Patient-derived Xenograft  
Proteolysis targeting chimeras (PROTACs) are emerging therapeutics for hematologic malignancies 期刊论文
JOURNAL OF HEMATOLOGY & ONCOLOGY, 2020, 卷号: 13, 期号: 1, 页码: 103
Authors:  He, Yonghan;  Khan, Sajid;  Huo, Zhiguang;  Lv, Dongwen;  Zhang X(张翾);  Liu, Xingui;  Yuan, Yaxia;  Hromas, Robert;  Xu, Mingjiang;  Zheng, Guangrong;  Zhou, Daohong
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Protac  Cell-specific E3 Ligases  Small Molecule Inhibitor  Hematologic Malignancy  
Deuteration of the farnesyl terminal methyl groups of delta-tocotrienol and its effects on the metabolic stability and ability of inducing G-CSF production 期刊论文
BIOORGANIC & MEDICINAL CHEMISTRY, 2020, 卷号: 28, 期号: 11, 页码: 115498
Authors:  Liu, Xingui;  Gao, Zhengya;  Fu, Qiang;  Song, Lin;  Zhang, Peiyi;  Zhang X(张翾);  Hendrickson, Howard;  Crooks, Peter A.;  Zhou, Daohong;  Zheng, Guangrong
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Tocotrienol  Deuteration  Metabolic Stability  Radio-protector  Pharmacokinetics  
PROteolysis TArgeting Chimeras (PROTACs) as emerging anticancer therapeutics 期刊论文
ONCOGENE, 2020, 卷号: 39, 期号: 26, 页码: 4909-4924
Authors:  Khan, Sajid;  He, Yonghan;  Zhang X(张翾);  Yuan, Yaxia;  Pu, Shaoyan;  Kong, Qingpeng;  Zheng, Guangrong;  Zhou, Daohong
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Using proteolysis-targeting chimera technology to reduce navitoclax platelet toxicity and improve its senolytic activity 期刊论文
NATURE COMMUNICATIONS, 2020, 卷号: 11, 期号: 1, 页码: 1996
Authors:  He, Yonghan;  Zhang X(张翾);  Chang, Jianhui;  Kim, Ha-Neui;  Zhang, Peiyi;  Wang, Yingying;  Khan, Sajid;  Liu, Xingui;  Zhang, Xin;  Lv, Dongwen;  Song, Lin;  Li, Wen;  Thummuri, Dinesh;  Yuan, Yaxia;  Wiegand, Janet S.;  Ortiz, Yuma T.;  Budamagunta, Vivekananda;  Elisseeff, Jennifer H.;  Campisi, Judith;  Almeida, Maria;  Zheng, Guangrong;  Zhou, Daohong
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Discovery of PROTAC BCL-X-L degraders as potent anticancer agents with low on-target platelet toxicity 期刊论文
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY, 2020, 卷号: 192, 页码: 112186
Authors:  Zhang X(张翾);  Thummuri, Dinesh;  Liu, Xingui;  Hu, Wanyi;  Zhang, Peiyi;  Khan, Sajid;  Yuan, Yaxia;  Zhou, Daohong;  Zheng, Guangrong
Favorite  |  View/Download:131/0  |  Submit date:2021/01/28
Bcl-x-l  Protac  Apoptosis  Platelet  Degradation  
Targeting anti-apoptotic BCL-2 family proteins for cancer treatment 期刊论文
FUTURE MEDICINAL CHEMISTRY, 2020, 卷号: 12, 期号: 7, 页码: 563-565
Authors:  Zhang X(张翾);  Liu, Xingui;  Zhou, Daohong;  Zheng, Guangrong
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Apoptosis  Bcl-2  Bcl-x-l  Cancer Treatment  Mcl-1  
Synthesis and Liver Microsomal Metabolic Stability Studies of a Fluorine-Substituted delta-Tocotrienol Derivative 期刊论文
CHEMMEDCHEM, 2020, 卷号: 15, 期号: 6, 页码: 506-516
Authors:  Liu, Xingui;  Poddar, Saikat;  Song, Lin;  Hendrickson, Howard;  Zhang X(张翾);  Yuan, Yaxia;  Zhou, Daohong;  Zheng, Guangrong
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Tocotrienol  Fluorination  Metabolic Stability  Synthesis  C-f Bond Hydrolysis